biostudies-literatureUnknown16(2)Xu H<h4>Introduction</h4>The WHO Package of Essential Non-communicable Diseases Interventions (WHO PEN) provides a core set of measures to prevent, detect and manage non-communicable diseases (NCDs) in low-resource settings. Many countries have adopted WHO PEN to strengthen primary healthcare, yet there is limited consolidated evidence on what components have been implemented and how WHO PEN has been implemented across different contexts. Understanding both the 'what' (disease modules, intervention activities, tools) and the 'how' (strategies, approaches, target populations and contextual factors) is crucial to assess the short-term to medium-term effects on health system readiness, provider performance, patient outcomes and long-term population health impact.This protocol outlines a systematiBMJ opene112469https://www.ebi.ac.uk/biostudies/studies/S-EPMC12927286biostudies-literatureEvidence on implementing WHO Package of Essential Non-communicable (PEN) Diseases Interventions: a systematic review protocol.PMC12927286Cieza AWu JYang JHu YQama EXu HLi MfalseEvidence on implementing WHO Package of Essential Non-communicable (PEN) Diseases Interventions: a systematic review protocol.<h4>Introduction</h4>The WHO Package of Essential Non-communicable Diseases Interventions (WHO PEN) provides a core set of measures to prevent, detect and manage non-communicable diseases (NCDs) in low-resource settings. Many countries have adopted WHO PEN to strengthen primary healthcare, yet there is limited consolidated evidence on what components have been implemented and how WHO PEN has been implemented across different contexts. Understanding both the 'what' (disease modules, intervention activities, tools) and the 'how' (strategies, approaches, target populations and contextual factors) is crucial to assess the short-term to medium-term effects on health system readiness, provider performance, patient outcomes and long-term population health impact.This protocol outlines a systemati2026-01-01T00:00:00Z2026 Feb2026-07-16T17:47:45.362Z2026-07-09T11:09:44.793ZS-EPMC129272864171392310.1136/bmjopen-2025-112469