{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Marrocco R"],"pubmed_abstract":["<h4>Background</h4>Immunotherapy has had limited success in pancreatic cancer, largely due to a low mutational burden and immunosuppressive microenvironment. Here we hypothesized that systemic delivery of viral antigens can redirect pre-existing antiviral immunity against pancreatic tumors.<h4>Methods</h4>Cytomegalovirus (CMV, a β-herpesvirus) was chosen, as the majority of the population is infected and it induces an extremely large/broad memory T-cell response. Mice latently infected with murine CMV (MCMV) were orthotopically implanted with pancreatic cancer cells and treated with systemic injections of MCMV T-cell epitopes. Tumor growth was monitored by ultrasound two times a week, and immune cell infiltration was analyzed by histology, flow cytometry and single-cell RNA sequencing (scR"],"journal":["Journal for immunotherapy of cancer"],"pagination":["e012969"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12927352"],"repository":["biostudies-literature"],"pubmed_title":["Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy."],"pmcid":["PMC12927352"],"pubmed_authors":["Gulay K","Maia C","Lowy A","Martsinkovskiy A","Jaljuli M","Lucero-Meza E","Salu P","Mose E","Benedict C","Sun S","Hurtado de Mendoza T","Marrocco R","Brunel S","Patel J","Medari R"],"additional_accession":[]},"is_claimable":false,"name":"Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy.","description":"<h4>Background</h4>Immunotherapy has had limited success in pancreatic cancer, largely due to a low mutational burden and immunosuppressive microenvironment. Here we hypothesized that systemic delivery of viral antigens can redirect pre-existing antiviral immunity against pancreatic tumors.<h4>Methods</h4>Cytomegalovirus (CMV, a β-herpesvirus) was chosen, as the majority of the population is infected and it induces an extremely large/broad memory T-cell response. Mice latently infected with murine CMV (MCMV) were orthotopically implanted with pancreatic cancer cells and treated with systemic injections of MCMV T-cell epitopes. Tumor growth was monitored by ultrasound two times a week, and immune cell infiltration was analyzed by histology, flow cytometry and single-cell RNA sequencing (scR","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:26:32.348Z","creation":"2026-07-09T11:14:25.838Z"},"accession":"S-EPMC12927352","cross_references":{"pubmed":["41638871"],"doi":["10.1136/jitc-2025-012969"]}}