{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Hungerford J"],"funding":["Horace H. Rackham School of Graduate Studies, University of Michigan","Hermann Frasch Foundation","Pharmaceutical Research and Manufacturers of America Foundation","New Mexico Department of Agriculture","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pubmed_abstract":["Cyclopeptide alkaloids are an expanding class of plant peptide natural products defined by a macrocyclic ether cross-link via a tyrosine-derived phenol. Classical cyclopeptide alkaloids are characterized by strained 13- to 15-membered cyclophanes and terminal modifications such as <i>N</i>-methylation and C-terminal styrylamine moieties. While synthetic access to many classical cyclopeptide alkaloids has been established, no biosynthetic route has been reported. Here, we elucidate the biosynthetic pathway of a 14-membered cyclopeptide alkaloid, lotusine A, from the Chinese date tree (<i>Ziziphus jujuba</i>), which features peptide cyclization on a ribosomal precursor peptide by a split burpitide cyclase, nonheme-iron and 2-oxoglutarate-dependent oxidative decarboxylation affording the C-te"],"journal":["Journal of the American Chemical Society"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12927610"],"repository":["biostudies-literature"],"pubmed_title":["Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation."],"pmcid":["PMC12927610"],"funding_grant_id":["T32GM140223","F32 GM146395","R35GM146934","R35 GM146934","F32GM146395","T32 GM140223","F31 GM155959","F31GM155959"],"pubmed_authors":["Li W","Shafiq K","Mydy LS","Mendoza-Perez L","May G","Chigumba DN","Hungerford J","Yao S","Kersten RD","Wang X","McDonough KM","Ousley DA"],"additional_accession":[]},"is_claimable":false,"name":"Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation.","description":"Cyclopeptide alkaloids are an expanding class of plant peptide natural products defined by a macrocyclic ether cross-link via a tyrosine-derived phenol. Classical cyclopeptide alkaloids are characterized by strained 13- to 15-membered cyclophanes and terminal modifications such as <i>N</i>-methylation and C-terminal styrylamine moieties. While synthetic access to many classical cyclopeptide alkaloids has been established, no biosynthetic route has been reported. Here, we elucidate the biosynthetic pathway of a 14-membered cyclopeptide alkaloid, lotusine A, from the Chinese date tree (<i>Ziziphus jujuba</i>), which features peptide cyclization on a ribosomal precursor peptide by a split burpitide cyclase, nonheme-iron and 2-oxoglutarate-dependent oxidative decarboxylation affording the C-te","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T17:48:26.936Z","creation":"2026-07-09T11:10:07.068Z"},"accession":"S-EPMC12927610","cross_references":{"pubmed":["41698050"],"doi":["10.1021/jacs.5c23400"]}}