{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun C"],"funding":["Brain Institute, University of Virginia","NIH HHS"],"pagination":["993-1006"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12927686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(2)"],"pubmed_abstract":["<h4>Objective</h4>Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure-related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine-induced SE affects respiration in mice.<h4>Methods</h4>We performed simultaneous plethysmographic, electroencephalographic, and electrocardiographic recordings in mice administered pilocarpine at 200, 240, or 280 mg/kg. We analyzed seizure progression, respiratory rate, ventilation, inspiratory/expiratory timing, and survival.<h4>Results</h4>Higher pilocarpine doses resulted in shorter latency to SE and increased mortality. Across all doses, respiratory frequency and ventilation increased from baseline through early and establish"],"journal":["Epilepsia"],"pubmed_title":["Respiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus."],"pmcid":["PMC12927686"],"funding_grant_id":["R37NS119012","R01 NS120945"],"pubmed_authors":["Spera R","Ganabady H","Guduru B","Williamson JM","Sun C","Kapur J","Joshi S"],"additional_accession":[]},"is_claimable":false,"name":"Respiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus.","description":"<h4>Objective</h4>Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure-related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine-induced SE affects respiration in mice.<h4>Methods</h4>We performed simultaneous plethysmographic, electroencephalographic, and electrocardiographic recordings in mice administered pilocarpine at 200, 240, or 280 mg/kg. We analyzed seizure progression, respiratory rate, ventilation, inspiratory/expiratory timing, and survival.<h4>Results</h4>Higher pilocarpine doses resulted in shorter latency to SE and increased mortality. Across all doses, respiratory frequency and ventilation increased from baseline through early and establish","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-09T12:06:58.176Z","creation":"2026-07-09T11:09:13.216Z"},"accession":"S-EPMC12927686","cross_references":{"pubmed":["41137579"],"doi":["10.1111/epi.18674"]}}