biostudies-literatureSun CBrain Institute, University of VirginiaNIH HHS993-1006https://www.ebi.ac.uk/biostudies/studies/S-EPMC12927686biostudies-literatureUnknown67(2)<h4>Objective</h4>Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure-related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine-induced SE affects respiration in mice.<h4>Methods</h4>We performed simultaneous plethysmographic, electroencephalographic, and electrocardiographic recordings in mice administered pilocarpine at 200, 240, or 280 mg/kg. We analyzed seizure progression, respiratory rate, ventilation, inspiratory/expiratory timing, and survival.<h4>Results</h4>Higher pilocarpine doses resulted in shorter latency to SE and increased mortality. Across all doses, respiratory frequency and ventilation increased from baseline through early and establishEpilepsiaRespiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus.PMC12927686R37NS119012R01 NS120945Spera RGanabady HGuduru BWilliamson JMSun CKapur JJoshi SfalseRespiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus.<h4>Objective</h4>Status epilepticus (SE) is second only to sudden unexpected death in epilepsy as a cause of seizure-related mortality. The progression of respiratory dysfunction during experimental SE remains poorly characterized. We investigated how pilocarpine-induced SE affects respiration in mice.<h4>Methods</h4>We performed simultaneous plethysmographic, electroencephalographic, and electrocardiographic recordings in mice administered pilocarpine at 200, 240, or 280 mg/kg. We analyzed seizure progression, respiratory rate, ventilation, inspiratory/expiratory timing, and survival.<h4>Results</h4>Higher pilocarpine doses resulted in shorter latency to SE and increased mortality. Across all doses, respiratory frequency and ventilation increased from baseline through early and establish2026-01-01T00:00:00Z2026 Feb2026-07-09T12:06:58.176Z2026-07-09T11:09:13.216ZS-EPMC129276864113757910.1111/epi.18674