biostudies-literatureUnknown83(3)Cheng YB<h4>Background</h4>The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.<h4>Methods</h4>In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure of 140 mm Hg.<h4>Results</h4>Over 10.7 years (median), 3027 all-cause deaths and 2183 cardiHypertension (Dallas, Tex. : 1979)e25442https://www.ebi.ac.uk/biostudies/studies/S-EPMC12928787biostudies-literatureEnd Point-Based Threshold for the Ambulatory Arterial Stiffness Index.PMC12928787An DWOlszanecka AHansen TWDolan ETatsumi YInternational Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes InvestigatorsTsubota-Utsugi MBanegas JRKang YYSheng CSTicha MO'Brien ESchettini CGraciani AIbsen HSandoya ESenra HFilipovsky JImai YZhang DYWang YHozawa AAsayama KStolarz-Skrzypek KCabanas VLebek-Szatanska APello ELi YStaessen JAHirose TKikuya MMelgarejo JDKawecka-Jaszcz KGuo QHMartens DSSeidlerova JMujaj BGilis-Malinowska NJeppesen JVerhamme PGrodzicki TSatoh MLopez-Garcia EBoggia JYang WYZyczkowska JNarkiewicz KVoevoda MCasiglia ELind LWizner BLubaszewski WBjorklund-Bodegard KHuang QFWang JGRajzer MCheng YBMurakami TOhkubo TCaballero FFSchwedt ERodriguez-Artalejo FGasowski JNawrot TSTikhonoff VBianchi MMetoki HYu YLCwynar MTorp-Pedersen CWei FFZhang WWojciechowska WMaestre GENomura KSimonova GLiu CHuang JFMalyutina SGuallar PZethelius BfalseEnd Point-Based Threshold for the Ambulatory Arterial Stiffness Index.<h4>Background</h4>The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.<h4>Methods</h4>In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure of 140 mm Hg.<h4>Results</h4>Over 10.7 years (median), 3027 all-cause deaths and 2183 cardi2026-01-01T00:00:00Z2026 Mar2026-07-16T18:32:10.46Z2026-07-11T03:08:53.435ZS-EPMC129287874150370610.1161/HYPERTENSIONAHA.125.25442