{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["650(8101)"],"submitter":["Zhang X"],"pubmed_abstract":["Type 1 conventional dendritic cells (cDC1s) are unique in their efferocytosis<sup>1</sup> and cross-presenting abilities<sup>2</sup>, resulting in antigen-specific T cell immunity<sup>3</sup> or tolerance<sup>4-8</sup>. However, the mechanisms that underlie cDC1 tolerogenic function remain largely unknown. Here we show that the erythropoietin receptor (EPOR) acts as a critical switch that determines the tolerogenic function of cDC1s and the threshold of antigen-specific T cell responses. In total lymphoid irradiation-induced allograft tolerance<sup>9,10</sup>, cDC1s upregulate EPOR expression, and conditional knockout of EPOR in cDC1s diminishes antigen-specific induction and expansion of FOXP3<sup>+</sup> regulatory T (T<sub>reg</sub>) cells, resulting in allograft rejection. Mechanistica"],"journal":["Nature"],"pagination":["470-480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12929016"],"repository":["biostudies-literature"],"pubmed_title":["Erythropoietin receptor on cDC1s dictates immune tolerance."],"pmcid":["PMC12929016"],"pubmed_authors":["Qiu J","Angelo M","Engleman EG","Guo W","Yu G","McGinnis CS","Chi H","Hickey JW","Qiu W","Way SS","Scharschmidt TC","An X","Chen S","Paidassi H","Hiam-Galvez KJ","Brichart-Vernos D","Xiao Y","Zheng P","Hirai T","Yao W","Malissen B","Tran VM","Yu B","Schurch CM","Zhang X","Strober S","Muselman A","Satpathy AT","Reticker-Flynn NE","Linde IL","Yan H","Sheppard D"],"additional_accession":[]},"is_claimable":false,"name":"Erythropoietin receptor on cDC1s dictates immune tolerance.","description":"Type 1 conventional dendritic cells (cDC1s) are unique in their efferocytosis<sup>1</sup> and cross-presenting abilities<sup>2</sup>, resulting in antigen-specific T cell immunity<sup>3</sup> or tolerance<sup>4-8</sup>. However, the mechanisms that underlie cDC1 tolerogenic function remain largely unknown. Here we show that the erythropoietin receptor (EPOR) acts as a critical switch that determines the tolerogenic function of cDC1s and the threshold of antigen-specific T cell responses. In total lymphoid irradiation-induced allograft tolerance<sup>9,10</sup>, cDC1s upregulate EPOR expression, and conditional knockout of EPOR in cDC1s diminishes antigen-specific induction and expansion of FOXP3<sup>+</sup> regulatory T (T<sub>reg</sub>) cells, resulting in allograft rejection. Mechanistica","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T18:28:17.49Z","creation":"2026-07-09T11:14:40.769Z"},"accession":"S-EPMC12929016","cross_references":{"pubmed":["41372415"],"doi":["10.1038/s41586-025-09824-z"]}}