biostudies-literatureOgurtsova KEssen Cultural FoundationHeinz Nixdorf StiftungDeutsche ForschungsgemeinschaftVolkswagen FoundationNIA NIH HHSNIEHS NIH HHSSeventh Framework ProgrammeLandesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen121830https://www.ebi.ac.uk/biostudies/studies/S-EPMC12930415biostudies-literatureUnknown279(Pt 2)<h4>Background</h4>Modifiable physical and social environments are believed to influence cognitive health in older age.<h4>Objectives</h4>To employ cutting-edge methods to analyze the impact of correlated environmental and socioeconomic neighborhood factors on cognitive function in German older participants.<h4>Methods</h4>In the German Heinz Nixdorf Recall cohort study, participants underwent neuropsychological testing at the first follow-up examination (2006-2008) to derive a global cognitive score (GCS). Long-term exposure to air pollution was estimated by the land-use regression and chemistry transport models. Road traffic noise was assessed as outdoor weighted 24h and nighttime means. Seven neighborhood-level socioeconomic position (nSEP) characteristics were linked from administrativEnvironmental researchJoint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study.PMC12930415211250ER 155/6-2ER 155/6-1R01 AG079170P30 ES019776Weimar CDragano NChristensen GMSoppa VJSchmidt BHuls AJokisch MTzivian LOgurtsova KHoffmann BfalseJoint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study.<h4>Background</h4>Modifiable physical and social environments are believed to influence cognitive health in older age.<h4>Objectives</h4>To employ cutting-edge methods to analyze the impact of correlated environmental and socioeconomic neighborhood factors on cognitive function in German older participants.<h4>Methods</h4>In the German Heinz Nixdorf Recall cohort study, participants underwent neuropsychological testing at the first follow-up examination (2006-2008) to derive a global cognitive score (GCS). Long-term exposure to air pollution was estimated by the land-use regression and chemistry transport models. Road traffic noise was assessed as outdoor weighted 24h and nighttime means. Seven neighborhood-level socioeconomic position (nSEP) characteristics were linked from administrativ2025-01-01T00:00:00Z2025 Aug2026-07-09T12:21:09.088Z2026-07-09T11:17:32.627ZS-EPMC129304154036804110.1016/j.envres.2025.121830