{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(7)"],"submitter":["Delattre M"],"funding":["?cole Polytechnique F?d?rale de Lausanne"],"pubmed_abstract":["Under acidic conditions, propargylic alcohols undergo Meyer-Schuster or Rupe rearrangements to afford two isomeric α,β-unsaturated ketones. Herein, we disclose a mechanistically distinct base-mediated regioselective conversion of TMS ethers of propargylic alcohols to 1,3-enynes in high yields with broad functional-group compatibility. Alternatively, trapping of the in situ-generated lithium acetylide with electrophiles enables access to functionalized internal 1,3-enynes. Owing to the ready accessibility of propargylic alcohols, this method provides a practical and attractive entry to synthetically valuable 1,3-enynes."],"journal":["Organic letters"],"pagination":["2500-2504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12930487"],"repository":["biostudies-literature"],"pubmed_title":["Base-Promoted Conversion of Propargylic Alcohols to 1,3-Enynes."],"pmcid":["PMC12930487"],"pubmed_authors":["Wiegand M","Delattre M","Wang Q","Zhu J"],"additional_accession":[]},"is_claimable":false,"name":"Base-Promoted Conversion of Propargylic Alcohols to 1,3-Enynes.","description":"Under acidic conditions, propargylic alcohols undergo Meyer-Schuster or Rupe rearrangements to afford two isomeric α,β-unsaturated ketones. Herein, we disclose a mechanistically distinct base-mediated regioselective conversion of TMS ethers of propargylic alcohols to 1,3-enynes in high yields with broad functional-group compatibility. Alternatively, trapping of the in situ-generated lithium acetylide with electrophiles enables access to functionalized internal 1,3-enynes. Owing to the ready accessibility of propargylic alcohols, this method provides a practical and attractive entry to synthetically valuable 1,3-enynes.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-09T12:23:14.423Z","creation":"2026-07-09T11:17:43.914Z"},"accession":"S-EPMC12930487","cross_references":{"pubmed":["41638917"],"doi":["10.1021/acs.orglett.6c00196"]}}