biostudies-literatureCheng MKthe National Natural Science Foundation of Chinathe Ministry of Science and Technology of Hubei2522970https://www.ebi.ac.uk/biostudies/studies/S-EPMC12931302biostudies-literatureUnknown57(1)<h4>Background</h4>Obesity is a known risk factor for diabetic peripheral neuropathy (DPN), but the relationship between body mass index (BMI) and DPN remains controversial.<h4>Aims</h4>This study explores the relationship between weight-adjusted waist index (WWI) and DPN in Chinese patients with Type 2 Diabetes Mellitus (T2DM), with the goal of establishing WWI as an effective tool for the early detection and risk stratification of DPN.<h4>Methods</h4>A total of 1790 participants were included. The relationships between WWI, BMI, WC, and DPN were analyzed using logistic regression, restricted cubic spline, and subgroup analysis, with ROC-AUC used to assess the diagnostic performance of the obesity indices.<h4>Results</h4>During this cross-sectional study, a total of 895 cases of DPN were Annals of medicinePredictive role of weight-adjusted waist index in diabetic peripheral neuropathy among patients with type 2 diabetes mellitus.PMC1293130282100922H.R, 82270855 G.YKang XNGuo YYZhang ZYWang DCheng MKRen HHYuan GfalsePredictive role of weight-adjusted waist index in diabetic peripheral neuropathy among patients with type 2 diabetes mellitus.<h4>Background</h4>Obesity is a known risk factor for diabetic peripheral neuropathy (DPN), but the relationship between body mass index (BMI) and DPN remains controversial.<h4>Aims</h4>This study explores the relationship between weight-adjusted waist index (WWI) and DPN in Chinese patients with Type 2 Diabetes Mellitus (T2DM), with the goal of establishing WWI as an effective tool for the early detection and risk stratification of DPN.<h4>Methods</h4>A total of 1790 participants were included. The relationships between WWI, BMI, WC, and DPN were analyzed using logistic regression, restricted cubic spline, and subgroup analysis, with ROC-AUC used to assess the diagnostic performance of the obesity indices.<h4>Results</h4>During this cross-sectional study, a total of 895 cases of DPN were 2025-01-01T00:00:00Z2025 Dec2026-07-09T12:20:32.323Z2026-07-09T11:17:30.172ZS-EPMC129313024055158710.1080/07853890.2025.2522970