{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pink A"],"funding":["GHR Foundation","Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic","Schuler Foundation","Mayo Foundation for Medical Education and Research","Arizona Alzheimer&apos;s Consortium","NIA NIH HHS","Arizona Alzheimers Consortium","Schuler-Stiftung","Liston Award","Barrow Neurological Foundation","National Institute on Aging","Robert H. and Clarice Smith and Abigail Van Buren Alzheimers Disease Research Program"],"pagination":["345-354"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12931372"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(2)"],"pubmed_abstract":["<h4>Background</h4>Previous studies on the relationship between prediabetes, HbA1c and cognitive trajectories show mixed results. Therefore, we investigated the association of prediabetes, diabetes and HbA1c with change in global and domain-specific cognitive scores in cognitively unimpaired (CU) adults, as well as the potential effect modification by sex or age.<h4>Methods</h4>This longitudinal study included 4236 CU persons aged ≥ 50 years from the population-based Mayo Clinic Study of Aging. We ran linear mixed-effect models with baseline prediabetes, diabetes and HbA1c predicting longitudinal global and domain-specific (i.e., memory, language, attention/executive function, and visuospatial skills) cognitive z-scores and raw scores. Models were adjusted for age, sex, education, medical "],"journal":["Journal of the American Geriatrics Society"],"pubmed_title":["A Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals."],"pmcid":["PMC12931372"],"funding_grant_id":["R37 AG011378","R01 AG041851","P30 AG062677","U01 AG006786","R01 AG057708","R01 NS097495"],"pubmed_authors":["Geda YE","Krell-Roesch J","Vassilaki M","Syrjanen JA","Fields JA","Jack CR","Pink A","Aigner E","Racette SB","Iglseder B","Kremers WK","Petersen RC"],"additional_accession":[]},"is_claimable":false,"name":"A Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals.","description":"<h4>Background</h4>Previous studies on the relationship between prediabetes, HbA1c and cognitive trajectories show mixed results. Therefore, we investigated the association of prediabetes, diabetes and HbA1c with change in global and domain-specific cognitive scores in cognitively unimpaired (CU) adults, as well as the potential effect modification by sex or age.<h4>Methods</h4>This longitudinal study included 4236 CU persons aged ≥ 50 years from the population-based Mayo Clinic Study of Aging. We ran linear mixed-effect models with baseline prediabetes, diabetes and HbA1c predicting longitudinal global and domain-specific (i.e., memory, language, attention/executive function, and visuospatial skills) cognitive z-scores and raw scores. Models were adjusted for age, sex, education, medical ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-09T12:24:11.215Z","creation":"2026-07-09T11:17:46.415Z"},"accession":"S-EPMC12931372","cross_references":{"pubmed":["41348388"],"doi":["10.1111/jgs.70231"]}}