biostudies-literaturePink AGHR FoundationAlexander Family Alzheimer's Disease Research Professorship of the Mayo ClinicSchuler FoundationMayo Foundation for Medical Education and ResearchArizona Alzheimer&apos;s ConsortiumNIA NIH HHSArizona Alzheimers ConsortiumSchuler-StiftungListon AwardBarrow Neurological FoundationNational Institute on AgingRobert H. and Clarice Smith and Abigail Van Buren Alzheimers Disease Research Program345-354https://www.ebi.ac.uk/biostudies/studies/S-EPMC12931372biostudies-literatureUnknown74(2)<h4>Background</h4>Previous studies on the relationship between prediabetes, HbA1c and cognitive trajectories show mixed results. Therefore, we investigated the association of prediabetes, diabetes and HbA1c with change in global and domain-specific cognitive scores in cognitively unimpaired (CU) adults, as well as the potential effect modification by sex or age.<h4>Methods</h4>This longitudinal study included 4236 CU persons aged ≥ 50 years from the population-based Mayo Clinic Study of Aging. We ran linear mixed-effect models with baseline prediabetes, diabetes and HbA1c predicting longitudinal global and domain-specific (i.e., memory, language, attention/executive function, and visuospatial skills) cognitive z-scores and raw scores. Models were adjusted for age, sex, education, medical Journal of the American Geriatrics SocietyA Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals.PMC12931372R37 AG011378R01 AG041851P30 AG062677U01 AG006786R01 AG057708R01 NS097495Geda YEKrell-Roesch JVassilaki MSyrjanen JAFields JAJack CRPink AAigner ERacette SBIglseder BKremers WKPetersen RCfalseA Longitudinal Investigation of Prediabetes, Diabetes, HbA1c and Cognitive Trajectories Among Cognitively Unimpaired Individuals.<h4>Background</h4>Previous studies on the relationship between prediabetes, HbA1c and cognitive trajectories show mixed results. Therefore, we investigated the association of prediabetes, diabetes and HbA1c with change in global and domain-specific cognitive scores in cognitively unimpaired (CU) adults, as well as the potential effect modification by sex or age.<h4>Methods</h4>This longitudinal study included 4236 CU persons aged ≥ 50 years from the population-based Mayo Clinic Study of Aging. We ran linear mixed-effect models with baseline prediabetes, diabetes and HbA1c predicting longitudinal global and domain-specific (i.e., memory, language, attention/executive function, and visuospatial skills) cognitive z-scores and raw scores. Models were adjusted for age, sex, education, medical 2026-01-01T00:00:00Z2026 Feb2026-07-09T12:24:11.215Z2026-07-09T11:17:46.415ZS-EPMC129313724134838810.1111/jgs.70231