{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bruder E"],"funding":["Weizmann Institute of Science","Agence Nationale de la Recherche"],"pagination":["2587402"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12931692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Patients with Crohn's disease exhibit abnormal intestinal colonization by <i>Proteobacteria</i>, particularly adherent-invasive <i>Escherichia coli</i> (AIEC). These bacteria predominate in the mucus, adhere to epithelial cells, colonize them, and survive inside macrophages. We recently demonstrated that the AIEC strain LF82 adapts to phagolysosomal stress through a two-step process: initial replication arrest generating stress-tolerant persisters, followed by the resumption of replication, leading to the formation of intracellular bacterial communities (IBCs) embedded in a biofilm-like matrix. Given the significant genomic diversity among strains with the AIEC phenotype, we performed a comparative genomic and functional analysis of 13 AIEC isolates from Crohn's disease patients in France "],"journal":["Gut microbes"],"pubmed_title":["Persistence mechanisms of Crohn's disease-associated adherent invasive &lt;i&gt;Escherichia coli&lt;/i&gt; within macrophages."],"pmcid":["PMC12931692"],"funding_grant_id":["WIS 714514-01","ANR-10-LABX-54 MEMOLIFE"],"pubmed_authors":["Espeli O","Quenech'Du N","Buisson A","Chevarin C","Vazeille E","Granotier M","Singh P","Barnich N","Bruder E","Nedjar H"],"additional_accession":[]},"is_claimable":false,"name":"Persistence mechanisms of Crohn's disease-associated adherent invasive &lt;i&gt;Escherichia coli&lt;/i&gt; within macrophages.","description":"Patients with Crohn's disease exhibit abnormal intestinal colonization by <i>Proteobacteria</i>, particularly adherent-invasive <i>Escherichia coli</i> (AIEC). These bacteria predominate in the mucus, adhere to epithelial cells, colonize them, and survive inside macrophages. We recently demonstrated that the AIEC strain LF82 adapts to phagolysosomal stress through a two-step process: initial replication arrest generating stress-tolerant persisters, followed by the resumption of replication, leading to the formation of intracellular bacterial communities (IBCs) embedded in a biofilm-like matrix. Given the significant genomic diversity among strains with the AIEC phenotype, we performed a comparative genomic and functional analysis of 13 AIEC isolates from Crohn's disease patients in France ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-09T12:26:13.393Z","creation":"2026-07-09T11:17:53.571Z"},"accession":"S-EPMC12931692","cross_references":{"pubmed":["41287568"],"doi":["10.1080/19490976.2025.2587402"]}}