biostudies-literatureUnknown13Guo P<h4>Background</h4>The extensive and intense itching caused by skin diseases can significantly diminish the quality of life for companion animals. Oral administration of oclacitinib maleate is recognized as an important treatment for alleviating itching. Oral medications are affected by the animal's temperament and swallowing ability.<h4>Methods</h4>In this study, we developed a temperature-responsive hydrogel containing oclacitinib maleate for rectal administration, and we evaluated its therapeutic potential for treating itching through pharmacokinetic analysis using rabbits as test subjects.<h4>Results</h4>Pharmacokinetic results indicated that the transrectal administration of OM T-R Hydrogel effectively increased the blood concentration of oclacitinib maleate (T_max = 87 min,Frontiers in veterinary science1767033https://www.ebi.ac.uk/biostudies/studies/S-EPMC12932137biostudies-literatureTemperature-responsive hydrogel of oclacitinib maleate administered via the rectum in rabbit.PMC12932137Yin GYang YMohsin MZhang ZGuo YWang DGuo PWu HWang LfalseTemperature-responsive hydrogel of oclacitinib maleate administered via the rectum in rabbit.<h4>Background</h4>The extensive and intense itching caused by skin diseases can significantly diminish the quality of life for companion animals. Oral administration of oclacitinib maleate is recognized as an important treatment for alleviating itching. Oral medications are affected by the animal's temperament and swallowing ability.<h4>Methods</h4>In this study, we developed a temperature-responsive hydrogel containing oclacitinib maleate for rectal administration, and we evaluated its therapeutic potential for treating itching through pharmacokinetic analysis using rabbits as test subjects.<h4>Results</h4>Pharmacokinetic results indicated that the transrectal administration of OM T-R Hydrogel effectively increased the blood concentration of oclacitinib maleate (T_max = 87 min,2026-01-01T00:00:00Z20262026-07-16T22:13:49.039Z2026-07-12T03:08:09.169ZS-EPMC129321374175658610.3389/fvets.2026.1767033