biostudies-literatureUnknown13Chen H<h4>Background</h4>Frailty is a global geriatric challenge requiring integrated nursing management. However, the mechanism driving nurses' practice behaviors remains unclear. This study aimed to evaluate the status of knowledge, attitude, and practice (KAP) regarding frailty syndrome among nurses and identify the independent predictors of clinical practice.<h4>Methods</h4>A multicenter cross-sectional survey was conducted among 598 registered nurses in Fujian, China, using a structured questionnaire. Data were analyzed using descriptive statistics and multiple linear regression to identify predictors of practice scores while adjusting for potential confounders.<h4>Results</h4>Participants demonstrated foundational theoretical knowledge of frailty definitions but exhibited substantial gaps Frontiers in medicine1659941https://www.ebi.ac.uk/biostudies/studies/S-EPMC12932247biostudies-literatureKnowledge, attitude, and practice of nurses towards frailty syndrome: a multicenter cross-sectional survey in Fujian Province, China.PMC12932247Lin PGuo JChen MLuan RSu MLin HChen HChen CHong PZhu BfalseKnowledge, attitude, and practice of nurses towards frailty syndrome: a multicenter cross-sectional survey in Fujian Province, China.<h4>Background</h4>Frailty is a global geriatric challenge requiring integrated nursing management. However, the mechanism driving nurses' practice behaviors remains unclear. This study aimed to evaluate the status of knowledge, attitude, and practice (KAP) regarding frailty syndrome among nurses and identify the independent predictors of clinical practice.<h4>Methods</h4>A multicenter cross-sectional survey was conducted among 598 registered nurses in Fujian, China, using a structured questionnaire. Data were analyzed using descriptive statistics and multiple linear regression to identify predictors of practice scores while adjusting for potential confounders.<h4>Results</h4>Participants demonstrated foundational theoretical knowledge of frailty definitions but exhibited substantial gaps 2026-01-01T00:00:00Z20262026-07-11T03:21:13.982Z2026-07-11T03:12:18.347ZS-EPMC129322474175639410.3389/fmed.2026.1659941