biostudies-literatureUnknown21(3)D'Anna LThis study was partially funded by the Graham-Dixon charity.<h4>Background</h4>High-density lipoprotein cholesterol (HDL-C) is traditionally considered protective in cardiovascular disease, but its role in acute ischemic stroke (AIS) remains unclear, particularly in patients undergoing mechanical thrombectomy (MT). This study aimed to assess the association between HDL-C levels and clinical outcomes in AIS patients treated with MT for anterior circulation large vessel occlusion (LVO).<h4>Methods</h4>We conducted a multicentre, observational, post hoc analysis of AIS patients treated with MT between January 2016 and March 2023 across three stroke centers. HDL-C levels at admission were categorized, and outcomes included 90-day functional dependence (mRS: 3-6), symptomatic intracranial hemorrhage (sICH), hemorrhagic transformation, and 90-day mortaliInternational journal of stroke : official journal of the International Stroke Society372-382https://www.ebi.ac.uk/biostudies/studies/S-EPMC12932689biostudies-literatureHigh-density lipoprotein cholesterol levels and their impact on outcomes in acute ischemic stroke patients treated with mechanical thrombectomy.PMC12932689D'Anna LFoschi MBanerjee SLobotesis KGigli GLValente MGavrilovic VMerlino GDel Regno CDe Negri IToraldo FSacco SMare APirera ESponza MfalseHigh-density lipoprotein cholesterol levels and their impact on outcomes in acute ischemic stroke patients treated with mechanical thrombectomy.<h4>Background</h4>High-density lipoprotein cholesterol (HDL-C) is traditionally considered protective in cardiovascular disease, but its role in acute ischemic stroke (AIS) remains unclear, particularly in patients undergoing mechanical thrombectomy (MT). This study aimed to assess the association between HDL-C levels and clinical outcomes in AIS patients treated with MT for anterior circulation large vessel occlusion (LVO).<h4>Methods</h4>We conducted a multicentre, observational, post hoc analysis of AIS patients treated with MT between January 2016 and March 2023 across three stroke centers. HDL-C levels at admission were categorized, and outcomes included 90-day functional dependence (mRS: 3-6), symptomatic intracranial hemorrhage (sICH), hemorrhagic transformation, and 90-day mortali2026-01-01T00:00:00Z2026 Mar2026-07-16T21:34:30.084Z2026-07-12T03:08:50.089ZS-EPMC129326894085112010.1177/17474930251374791