biostudies-literatureUnknown31(7)Vieira Toledo RSWe report a case of a young woman who presented with a rapidly growing and aggressive diffuse large B-cell lymphoma with mediastinal and myocardial infiltration and involvement of the pulmonary trunk and coronary arteries. A noninvasive multimodality imaging assessment was performed with transthoracic echocardiography, computed tomography, and cardiac magnetic resonance. Although this approach may allow for a precise and timely characterization of myocardial infiltration and thus demonstrate therapeutic implications, large B-cell lymphoma has been rarely documented using contemporary multimodality imaging techniques. This report underscores the value of a multimodality diagnostic strategy, illustrating the incremental contribution of each routinely available imaging modality to achieve proJACC. Case reports106571https://www.ebi.ac.uk/biostudies/studies/S-EPMC12932998biostudies-literatureLarge B-Cell Lymphoma Invading the Heart: Insights From Multimodality Imaging in a Young Woman.PMC12932998Vinicius de Paula EAntonio de Souza CDuffles GBau AARibeiro VCVieira Toledo RSTairova MSCoy-Cangucu ACoelho-Filho ORMartins CNBraga JBfalseLarge B-Cell Lymphoma Invading the Heart: Insights From Multimodality Imaging in a Young Woman.We report a case of a young woman who presented with a rapidly growing and aggressive diffuse large B-cell lymphoma with mediastinal and myocardial infiltration and involvement of the pulmonary trunk and coronary arteries. A noninvasive multimodality imaging assessment was performed with transthoracic echocardiography, computed tomography, and cardiac magnetic resonance. Although this approach may allow for a precise and timely characterization of myocardial infiltration and thus demonstrate therapeutic implications, large B-cell lymphoma has been rarely documented using contemporary multimodality imaging techniques. This report underscores the value of a multimodality diagnostic strategy, illustrating the incremental contribution of each routinely available imaging modality to achieve pro2026-01-01T00:00:00Z2026 Feb2026-07-16T21:39:42.403Z2026-07-10T03:15:25.949ZS-EPMC129329984170980810.1016/j.jaccas.2025.106571