{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan P"],"funding":["Breast Cancer Research Foundation (BCRF)","Center for Strategic Scientific Initiatives, National Cancer Institute (CSSI)","Israel Cancer Research Foundation","Samuel Waxman Cancer Research Foundation (SWCRF)","Israel Science Foundation (ISF)","HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute (DCP, NCI)"],"pagination":["e2523254123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["123(8)"],"pubmed_abstract":["Aging is a major risk factor for breast cancer, yet how it shapes tumor development, molecular phenotype, and immune evasion remains incompletely understood. Deciphering how aging influences cancer evolution is critical for improving risk assessment, prevention, and treatment. Here, using a N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model that recapitulates key features of human breast cancer, we integrated bulk and single-cell transcriptomics, whole-exome sequencing, and histopathological analysis to dissect age-associated differences in mammary tumorigenesis. We found that the age at NMU exposure critically influences tumor incidence, mutational burden, molecular subtype, and the tumor immune microenvironment. Tumors arising in aged rats originated from aging luminal progenit"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer."],"pmcid":["PMC12933083"],"funding_grant_id":["CA236754","NA","ICRF 1286740","ISF 2802/22","CA197623"],"pubmed_authors":["Cohen O","McAllister SS","Bui T","Polyak K","Yan P","Xu S","Sklartz M","P Paweletz C","Kuang Y","Haimov H","Rojas Jimenez E"],"additional_accession":[]},"is_claimable":false,"name":"Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer.","description":"Aging is a major risk factor for breast cancer, yet how it shapes tumor development, molecular phenotype, and immune evasion remains incompletely understood. Deciphering how aging influences cancer evolution is critical for improving risk assessment, prevention, and treatment. Here, using a N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model that recapitulates key features of human breast cancer, we integrated bulk and single-cell transcriptomics, whole-exome sequencing, and histopathological analysis to dissect age-associated differences in mammary tumorigenesis. We found that the age at NMU exposure critically influences tumor incidence, mutational burden, molecular subtype, and the tumor immune microenvironment. Tumors arising in aged rats originated from aging luminal progenit","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T20:49:47.048Z","creation":"2026-07-10T03:12:10.061Z"},"accession":"S-EPMC12933083","cross_references":{"pubmed":["41719331"],"doi":["10.1073/pnas.2523254123"]}}