{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Jin S"],"pubmed_abstract":["Polyester formation by polycondensation in water is limited by an esterification-hydrolysis equilibrium that strongly favors hydrolysis under mild conditions. Although aqueous-phase esterification has been demonstrated with chemical catalysts and isolated enzymes, these systems typically target small-molecule esters or rely on preactivated donors. The polyhydroxyalkanoate (PHA) pathway is the only known native metabolic route for polyester biosynthesis, but it is essentially limited to the polymerization of 3-hydroxybutyrate and related short-chain hydroxyalkanoate monomers. Consequently, realizing efficient aqueous-phase polycondensation to high-molar-mass polyesters remains a major challenge. Here, an intracellular CoA activation/acyltransferase cascade (ACOS5 <sub><i>At</i></sub> -WS2 <"],"journal":["JACS Au"],"pagination":["1347-1358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933353"],"repository":["biostudies-literature"],"pubmed_title":["Aqueous-Phase Polycondensation of Hydroxy Fatty Acids via a Whole-Cell CoA Activation-Acyltransferase Cascade."],"pmcid":["PMC12933353"],"pubmed_authors":["Liu J","Jin S","Wu Q","Zhang Y","Baeyens J","Lu D","Wang F","Nie K","Deng L","Jiang N"],"additional_accession":[]},"is_claimable":false,"name":"Aqueous-Phase Polycondensation of Hydroxy Fatty Acids via a Whole-Cell CoA Activation-Acyltransferase Cascade.","description":"Polyester formation by polycondensation in water is limited by an esterification-hydrolysis equilibrium that strongly favors hydrolysis under mild conditions. Although aqueous-phase esterification has been demonstrated with chemical catalysts and isolated enzymes, these systems typically target small-molecule esters or rely on preactivated donors. The polyhydroxyalkanoate (PHA) pathway is the only known native metabolic route for polyester biosynthesis, but it is essentially limited to the polymerization of 3-hydroxybutyrate and related short-chain hydroxyalkanoate monomers. Consequently, realizing efficient aqueous-phase polycondensation to high-molar-mass polyesters remains a major challenge. Here, an intracellular CoA activation/acyltransferase cascade (ACOS5 <sub><i>At</i></sub> -WS2 <","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:30:40.256Z","creation":"2026-07-11T03:11:59.479Z"},"accession":"S-EPMC12933353","cross_references":{"pubmed":["41755814"],"doi":["10.1021/jacsau.5c01683"]}}