biostudies-literatureLu HNational Natural Science Foundation of China1079-1088https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933364biostudies-literatureUnknown6(2)Secure information encryption is paramount in modern society for data protection, anticounterfeiting, and confidential communication. Here, we report the first demonstration of radiochromic metal-organic frameworks (MOFs) for high-security information encryption, leveraging their unique X-ray-induced chromic responses. Three thorium-based MOFs (Htpc⊂TOF, Hmpc⊂TOF, and Hpybz⊂TOF) were rationally constructed by embedding distinct pyridine-derived guest molecules within a robust layered Th6(μ3-O)4(μ3-OH)4(HCOO)12(DMF)2·2DMF host framework. Remarkably, upon X-ray irradiation, each framework exhibits well-defined and distinguishable color transformations, including purple for <JACS AuEmergence of Radiochromic Metal-Organic Frameworks for Information Encryption via Dual-Stimuli Responses.PMC1293336422322609U22B20139Yang JQian JChen QLu HChen JWang CZhang ZHMa JHe MYLin JfalseEmergence of Radiochromic Metal-Organic Frameworks for Information Encryption via Dual-Stimuli Responses.Secure information encryption is paramount in modern society for data protection, anticounterfeiting, and confidential communication. Here, we report the first demonstration of radiochromic metal-organic frameworks (MOFs) for high-security information encryption, leveraging their unique X-ray-induced chromic responses. Three thorium-based MOFs (Htpc⊂TOF, Hmpc⊂TOF, and Hpybz⊂TOF) were rationally constructed by embedding distinct pyridine-derived guest molecules within a robust layered Th6(μ3-O)4(μ3-OH)4(HCOO)12(DMF)2·2DMF host framework. Remarkably, upon X-ray irradiation, each framework exhibits well-defined and distinguishable color transformations, including purple for <2026-01-01T00:00:00Z2026 Feb2026-07-16T22:13:17.38Z2026-07-12T03:07:26.981ZS-EPMC129333644175582310.1021/jacsau.5c01489