{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang X"],"funding":["National Natural Science Foundation of China"],"pagination":["100860"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933437"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81"],"pubmed_abstract":["<h4>Background</h4>A diagnostic nomogram for predicting tubulointerstitial lesions (T1/2) in IgA Nephropathy (IgAN), developed in Guangzhou (GZ) using estimated Glomerular Filtration Rate (eGFR) and Urinary Protein Excretion (UPE), demonstrated high accuracy (AUC = 0.92) but lacked external validation.<h4>Methods</h4>The authors externally validated the nomogram in an independent cohort from Kunming (KM, n = 387; median altitude: 1,891 m), including a high-altitude subgroup (> 2,000 m, n = 155). Model performance was evaluated using Receiver Operating Characteristic (ROC) curves, calibration plots, and Decision Curve Analysis (DCA). Both creatinine-based eGFR (eGFRcr) and Creatinine-Cystatin C-based eGFR (eGFRcr-cys), each combined with UPE, were assessed.<h4>Results</h4>The nomogram achie"],"journal":["Clinics (Sao Paulo, Brazil)"],"pubmed_title":["External validation of a nomogram for predicting tubulointerstitial lesions in IgA nephropathy: a cross-regional study in China."],"pmcid":["PMC12933437"],"funding_grant_id":["82460150"],"pubmed_authors":["Yang M","Deng Q","Xu J","Zhao Y","Song L","Sun L","Wang Q","Pu L","Wang X","Shen Y","Meng H","Liu F","Xu Y","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"External validation of a nomogram for predicting tubulointerstitial lesions in IgA nephropathy: a cross-regional study in China.","description":"<h4>Background</h4>A diagnostic nomogram for predicting tubulointerstitial lesions (T1/2) in IgA Nephropathy (IgAN), developed in Guangzhou (GZ) using estimated Glomerular Filtration Rate (eGFR) and Urinary Protein Excretion (UPE), demonstrated high accuracy (AUC = 0.92) but lacked external validation.<h4>Methods</h4>The authors externally validated the nomogram in an independent cohort from Kunming (KM, n = 387; median altitude: 1,891 m), including a high-altitude subgroup (> 2,000 m, n = 155). Model performance was evaluated using Receiver Operating Characteristic (ROC) curves, calibration plots, and Decision Curve Analysis (DCA). Both creatinine-based eGFR (eGFRcr) and Creatinine-Cystatin C-based eGFR (eGFRcr-cys), each combined with UPE, were assessed.<h4>Results</h4>The nomogram achie","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T20:44:09.087Z","creation":"2026-07-10T03:11:03.531Z"},"accession":"S-EPMC12933437","cross_references":{"pubmed":["41720055"],"doi":["10.1016/j.clinsp.2026.100860"]}}