biostudies-literatureUnknown28(1)Showler L<h4>Objective</h4>Patients in the intensive care unit (ICU) suffer from disturbed sleep and pharmacological sleep aids are frequently prescribed despite limited data on their efficacy. The objective of this study was to assess the effect of a single nocturnal dose of the benzodiazepine temazepam on sleep duration and quality in ICU patients.<h4>Design</h4>Prospective, single-centre, blinded, placebo-controlled, parallel-group, randomised clinical trial.<h4>Setting</h4>A tertiary ICU in Australia.<h4>Participants</h4>Adult ICU patients whose treating clinician considered that a pharmacological sleep aid was indicated.<h4>Interventions</h4>A single weight- and age-adjusted dose of temazepam (10-30 mg) or a matching placebo was administered enterally at 21:00 h.<h4>Main outcome measures</h4>TCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine100169https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933563biostudies-literatureA pilot, parallel-group, blinded, placebo-controlled, randomise&lt;b&gt;D&lt;/b&gt;, p&lt;b&gt;R&lt;/b&gt;agmatic clinical trial investigating the &lt;b&gt;E&lt;/b&gt;ffect of temazep&lt;b&gt;AM&lt;/b&gt; on objective and subjective measures of sleep in critically ill patients (the DREAM trial).PMC12933563Kee KAli Abdelhamid YGoldin JJohnston BPerkins AByrne KDeane AMShowler LAnkravs MJMoore CPresneill JTascone BPlummer MPfalseA pilot, parallel-group, blinded, placebo-controlled, randomise&lt;b&gt;D&lt;/b&gt;, p&lt;b&gt;R&lt;/b&gt;agmatic clinical trial investigating the &lt;b&gt;E&lt;/b&gt;ffect of temazep&lt;b&gt;AM&lt;/b&gt; on objective and subjective measures of sleep in critically ill patients (the DREAM trial).<h4>Objective</h4>Patients in the intensive care unit (ICU) suffer from disturbed sleep and pharmacological sleep aids are frequently prescribed despite limited data on their efficacy. The objective of this study was to assess the effect of a single nocturnal dose of the benzodiazepine temazepam on sleep duration and quality in ICU patients.<h4>Design</h4>Prospective, single-centre, blinded, placebo-controlled, parallel-group, randomised clinical trial.<h4>Setting</h4>A tertiary ICU in Australia.<h4>Participants</h4>Adult ICU patients whose treating clinician considered that a pharmacological sleep aid was indicated.<h4>Interventions</h4>A single weight- and age-adjusted dose of temazepam (10-30 mg) or a matching placebo was administered enterally at 21:00 h.<h4>Main outcome measures</h4>T2026-01-01T00:00:00Z2026 Mar2026-07-16T22:12:15.889Z2026-07-12T03:06:49.413ZS-EPMC129335634175626310.1016/j.ccrj.2026.100169