{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Y"],"funding":["Shanghai Songjiang District Research Foundation","Basic and Applied Basic Research Foundation of Guangdong Province","National Natural Science Foundation of China"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933926"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(1)"],"pubmed_abstract":["<h4>Background</h4>Autoimmune inflammation results from dysregulated immune responses, with dysfunction of regulatory T cells (Tregs) being a key contributor due to their critical role in maintaining immune tolerance. The stability and function of Tregs are strongly influenced by the inflammatory microenvironment, yet the regulatory interactions between CD8<sup>+</sup> T cells and CD4<sup>+</sup>Foxp3<sup>+</sup> Tregs remain poorly understood.<h4>Methods</h4>We investigated the role of CD8<sup>+</sup> T cells in regulating induced Tregs (iTregs) using in vitro T cell co-culture assays and two in vivo models of autoimmune disease. A naïve CD4<sup>+</sup> T cell transfer colitis model was used to evaluate the suppressive function of iTregs in the presence or absence of CD8<sup>+</sup> T cel"],"journal":["Journal of biomedical science"],"pubmed_title":["TGF-β signaling mediates crosstalk between CD8&lt;sup&gt;+&lt;/sup&gt; T cells and CD39&lt;sup&gt;+&lt;/sup&gt; induced Treg cells in autoimmune inflammation."],"pmcid":["PMC12933926"],"funding_grant_id":["82371817","82001727","2024SJKJGG059","2022A1515111173","81871224","2024SJKJGG076"],"pubmed_authors":["Liang RZ","Chen JR","Liu L","Lu Y","Dang JL","Zhao W","Xiong YD","Zheng SG","Long Q","Wang J","Zang N","Yang Y","Olsen N","Chen Y","Zhao J","Pan YF"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β signaling mediates crosstalk between CD8&lt;sup&gt;+&lt;/sup&gt; T cells and CD39&lt;sup&gt;+&lt;/sup&gt; induced Treg cells in autoimmune inflammation.","description":"<h4>Background</h4>Autoimmune inflammation results from dysregulated immune responses, with dysfunction of regulatory T cells (Tregs) being a key contributor due to their critical role in maintaining immune tolerance. The stability and function of Tregs are strongly influenced by the inflammatory microenvironment, yet the regulatory interactions between CD8<sup>+</sup> T cells and CD4<sup>+</sup>Foxp3<sup>+</sup> Tregs remain poorly understood.<h4>Methods</h4>We investigated the role of CD8<sup>+</sup> T cells in regulating induced Tregs (iTregs) using in vitro T cell co-culture assays and two in vivo models of autoimmune disease. A naïve CD4<sup>+</sup> T cell transfer colitis model was used to evaluate the suppressive function of iTregs in the presence or absence of CD8<sup>+</sup> T cel","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T20:49:36.639Z","creation":"2026-07-10T03:12:05.327Z"},"accession":"S-EPMC12933926","cross_references":{"pubmed":["41736071"],"doi":["10.1186/s12929-026-01228-z"]}}