{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu X"],"funding":["National Natural Science Foundation of China"],"pagination":["5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12933981"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Objective</h4>To develop and evaluate a quercetin-loaded silicon dioxide-graphene nanocomposite (Que@SiO₂-GNPs) for targeted macrophage modulation and epithelial protection in a Mycoplasma-induced pneumonia model.<h4>Methods</h4>Que@SiO₂-GNPs were synthesized via graphene oxide dispersion, sol-gel silica coating, and quercetin adsorption. Physicochemical properties were characterized by XPS, XRD, and FTIR. The therapeutic efficacy was evaluated in MP-infected rat models via histopathology, ELISA, flow cytometry, immunostaining, and Western blot. Cellular uptake, polarization, and functional assays were performed in primary AMs and BEAS-2B epithelial cells.<h4>Results</h4>Que@SiO₂-GNPs exhibited successful surface modification and quercetin incorporation with stable physicochemical prop"],"journal":["Journal of inflammation (London, England)"],"pubmed_title":["Quercetin-loaded silicon dioxide-graphene nanoparticles promotes M2 macrophage reprogramming in mycoplasma-induced pneumonia."],"pmcid":["PMC12933981"],"funding_grant_id":["81804144"],"pubmed_authors":["Liu X","Jiang Y","Li W","Li X","Jiang Z","Chen X","Fei X"],"additional_accession":[]},"is_claimable":false,"name":"Quercetin-loaded silicon dioxide-graphene nanoparticles promotes M2 macrophage reprogramming in mycoplasma-induced pneumonia.","description":"<h4>Objective</h4>To develop and evaluate a quercetin-loaded silicon dioxide-graphene nanocomposite (Que@SiO₂-GNPs) for targeted macrophage modulation and epithelial protection in a Mycoplasma-induced pneumonia model.<h4>Methods</h4>Que@SiO₂-GNPs were synthesized via graphene oxide dispersion, sol-gel silica coating, and quercetin adsorption. Physicochemical properties were characterized by XPS, XRD, and FTIR. The therapeutic efficacy was evaluated in MP-infected rat models via histopathology, ELISA, flow cytometry, immunostaining, and Western blot. Cellular uptake, polarization, and functional assays were performed in primary AMs and BEAS-2B epithelial cells.<h4>Results</h4>Que@SiO₂-GNPs exhibited successful surface modification and quercetin incorporation with stable physicochemical prop","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T20:45:14.473Z","creation":"2026-07-10T03:11:30.07Z"},"accession":"S-EPMC12933981","cross_references":{"pubmed":["41715094"],"doi":["10.1186/s12950-026-00484-y"]}}