{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(7)"],"submitter":["Righetti GIC"],"pubmed_abstract":["The development of greener extraction systems is essential to improving the sustainability of biomass valorization processes. Here we report that 5-hydroxymethylfurfural (HMF) and levulinic acid (LEV)two bioderived platform molecules often coproduced in biomass processingspontaneously form a stable liquid phase over a broad compositional range. Differential scanning calorimetry (DSC) and thermodynamic modeling reveal a eutectic composition near <i>x</i> <sub>HMF</sub> = 0.39 with a melting temperature of 258 K and significant negative deviation from ideal behavior. The mixture remains liquid across a wide compositional range even in the presence of low water content (0.3-1.0 wt %), exhibiting deep eutectic solvent (DES)-like behavior. Structural and dynamic analyses using DSC, NMR spectr"],"journal":["ACS sustainable chemistry & engineering"],"pagination":["3699-3710"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12934199"],"repository":["biostudies-literature"],"pubmed_title":["Stable and Water-Tolerant Deep Eutectic Solvent from Biomass-Derived 5‑Hydroxymethylfurfural (HMF) and Levulinic Acid."],"pmcid":["PMC12934199"],"pubmed_authors":["Di Pietro ME","Santamaria S","Nasrallah S","Mele A","Minceva M","Vangosa FB","Aparicio S","Righetti GIC","Rozas S"],"additional_accession":[]},"is_claimable":false,"name":"Stable and Water-Tolerant Deep Eutectic Solvent from Biomass-Derived 5‑Hydroxymethylfurfural (HMF) and Levulinic Acid.","description":"The development of greener extraction systems is essential to improving the sustainability of biomass valorization processes. Here we report that 5-hydroxymethylfurfural (HMF) and levulinic acid (LEV)two bioderived platform molecules often coproduced in biomass processingspontaneously form a stable liquid phase over a broad compositional range. Differential scanning calorimetry (DSC) and thermodynamic modeling reveal a eutectic composition near <i>x</i> <sub>HMF</sub> = 0.39 with a melting temperature of 258 K and significant negative deviation from ideal behavior. The mixture remains liquid across a wide compositional range even in the presence of low water content (0.3-1.0 wt %), exhibiting deep eutectic solvent (DES)-like behavior. Structural and dynamic analyses using DSC, NMR spectr","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:57:37.625Z","creation":"2026-07-12T03:09:48.578Z"},"accession":"S-EPMC12934199","cross_references":{"pubmed":["41756684"],"doi":["10.1021/acssuschemeng.5c13551"]}}