{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Sharma C"],"funding":["National Heart, Lung, and Blood Institute","National Institutes of Health"],"pubmed_abstract":["We present a novel one-step methodology for direct mass spectrometric characterization of sulfated non-saccharide glycosaminoglycan mimetics in their sodiated form using the high reactivity of trifluorodiazoethane to form hydrophobic and chemically stable esters that facilitates separation and detection in a liquid chromatography-mass spectrometry system. The methodology preserves all sulfates present in the parent molecule, thereby allowing for accurate mass characterization of the per-sulfated molecule."],"journal":["Analytical methods : advancing methods and applications"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12934201"],"repository":["biostudies-literature"],"pubmed_title":["A one-step chemical derivatization strategy for mass spectrometric characterization of synthetic mimetics of sulfated glycosaminoglycans."],"pmcid":["PMC12934201"],"funding_grant_id":["P01 HL151333","R00 HL161423","R61/33 HL161813"],"pubmed_authors":["Sharma C","Afosah DK","Desai UR","Villuri BK"],"additional_accession":[]},"is_claimable":false,"name":"A one-step chemical derivatization strategy for mass spectrometric characterization of synthetic mimetics of sulfated glycosaminoglycans.","description":"We present a novel one-step methodology for direct mass spectrometric characterization of sulfated non-saccharide glycosaminoglycan mimetics in their sodiated form using the high reactivity of trifluorodiazoethane to form hydrophobic and chemically stable esters that facilitates separation and detection in a liquid chromatography-mass spectrometry system. The methodology preserves all sulfates present in the parent molecule, thereby allowing for accurate mass characterization of the per-sulfated molecule.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-10T03:24:20.671Z","creation":"2026-07-10T03:16:12.383Z"},"accession":"S-EPMC12934201","cross_references":{"pubmed":["41738625"],"doi":["10.1039/d5ay01855b"]}}