biostudies-literatureJiang LJiangsu Province Natural Science FoundationJiangsu Province Department of Science and TechnologyChangzhou Science and Technology BureauNational Key Research and Development Program of China Stem Cell and Translational ResearchNanjing Medical UniversityNational Natural Science Foundation of ChinaNational Key Research and Development Program of China100504https://www.ebi.ac.uk/biostudies/studies/S-EPMC12934294biostudies-literatureUnknown13(4)<h4>Background</h4>Using the Diffusion Tensor Image Analysis Along the Perivascular Space (ALPS) method and perivascular space (PVS) burden to study glymphatic function in high-risk Alzheimer's disease (AD) populations, this research investigates the correlation between ALPS index and PVS volume with cognitive function respectively.<h4>Methods</h4>This study enrolled 126 participants, including 21 cognitively unimpaired (CU) individuals, 68 with subjective cognitive decline (SCD), and 37 with mild cognitive impairment (MCI). All participants underwent MRI and cognitive assessments. MRI measures, including the PVS burden and the ALPS index, were compared across SCD, MCI, and CU groups. Additionally, correlations among the ALPS index, PVS burden, and cognitive scales were analyzed.<h4>ResultThe journal of prevention of Alzheimer's diseaseAssociation between MRI indicators of the glymphatic system and cognition in high-risk populations for Alzheimer's disease.PMC12934294BK20241120LC2024001BE2023778824017882023YFC3603605Jiang LQi MZhu YWu SXGao JWTian SZhu QQWang WZhang LfalseAssociation between MRI indicators of the glymphatic system and cognition in high-risk populations for Alzheimer's disease.<h4>Background</h4>Using the Diffusion Tensor Image Analysis Along the Perivascular Space (ALPS) method and perivascular space (PVS) burden to study glymphatic function in high-risk Alzheimer's disease (AD) populations, this research investigates the correlation between ALPS index and PVS volume with cognitive function respectively.<h4>Methods</h4>This study enrolled 126 participants, including 21 cognitively unimpaired (CU) individuals, 68 with subjective cognitive decline (SCD), and 37 with mild cognitive impairment (MCI). All participants underwent MRI and cognitive assessments. MRI measures, including the PVS burden and the ALPS index, were compared across SCD, MCI, and CU groups. Additionally, correlations among the ALPS index, PVS burden, and cognitive scales were analyzed.<h4>Result2026-01-01T00:00:00Z2026 Feb2026-07-16T21:34:32.506Z2026-07-12T03:08:50.553ZS-EPMC129342944172227710.1016/j.tjpad.2026.100504