{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["58(1)"],"submitter":["Kim J"],"pubmed_abstract":["<h4>Background</h4>The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation.<h4>Methods</h4>This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extracted from the Korean National Health Insurance System database between 2002 and 2021.<h4>Results</h4>Among these patients, 3,566 (29.6%) were categorized into the surgery group, while 8,481 (70.4%) were included in the nonsurgery group. Surgery was independently associated with both prolonged overall survival (OS) and a favorable prognosis in multivariate analysis (Hazard Ratio [HR] = 0.645, 95% Confidence Interval [CI] = 0.598-0.695, <i>p</i> <.001). The median OS was longer in patients who underwent lymph node dissection during surgery than in patients who did not undergo lymph node dissection (10-year OS with lymph node dissection 63.17% vs. surgery without lymph node dissection 54.78%, <i>p</i> < .001).<h4>Conclusions</h4>To our knowledge, this is the first Korean population-based nationwide study to describe the clinical impact of surgery on the OS of patients with intestinal NHL. A prospective randomized study evaluating strategies to improve the survival of intestinal NHL patients is needed."],"journal":["Annals of medicine"],"pagination":["2634447"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12934337"],"repository":["biostudies-literature"],"pubmed_title":["The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study."],"pmcid":["PMC12934337"],"pubmed_authors":["Hwang SH","Choi JH","Kim J","Hur JY","Won YW","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.","description":"<h4>Background</h4>The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation.<h4>Methods</h4>This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extracted from the Korean National Health Insurance System database between 2002 and 2021.<h4>Results</h4>Among these patients, 3,566 (29.6%) were categorized into the surgery group, while 8,481 (70.4%) were included in the nonsurgery group. Surgery was independently associated with both prolonged overall survival (OS) and a favorable prognosis in multivariate analysis (Hazard Ratio [HR] = 0.645, 95% Confidence Interval [CI] = 0.598-0.695, <i>p</i> <.001). The median OS was longer in patients who underwent lymph node dissection during surgery than in patients who did not undergo lymph node dissection (10-year OS with lymph node dissection 63.17% vs. surgery without lymph node dissection 54.78%, <i>p</i> < .001).<h4>Conclusions</h4>To our knowledge, this is the first Korean population-based nationwide study to describe the clinical impact of surgery on the OS of patients with intestinal NHL. A prospective randomized study evaluating strategies to improve the survival of intestinal NHL patients is needed.","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Dec","modification":"2026-07-10T03:26:20.384Z","creation":"2026-07-10T03:16:25.896Z"},"accession":"S-EPMC12934337","cross_references":{"pubmed":["41732903"],"doi":["10.1080/07853890.2026.2634447"]}}