biostudies-literatureUnknown58(1)Kim J<h4>Background</h4>The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation.<h4>Methods</h4>This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extracted from the Korean National Health Insurance System database between 2002 and 2021.<h4>Results</h4>Among these patients, 3,566 (29.6%) were categorized into the surgery group, while 8,481 (70.4%) were included in the nonsurgery group. Surgery was independently associated with both prolonged overall survival (OS) and a favorable prognosis in multivariate analysis (Hazard Ratio [HR] = 0.645, 95% Confidence Interval [CI] = 0.598-0.695, <i>p</i> <.001). The median OS was longer in patients who underwent lymph node dissection during surgery than in patients who did not undergo lymph node dissection (10-year OS with lymph node dissection 63.17% vs. surgery without lymph node dissection 54.78%, <i>p</i> < .001).<h4>Conclusions</h4>To our knowledge, this is the first Korean population-based nationwide study to describe the clinical impact of surgery on the OS of patients with intestinal NHL. A prospective randomized study evaluating strategies to improve the survival of intestinal NHL patients is needed.Annals of medicine2634447https://www.ebi.ac.uk/biostudies/studies/S-EPMC12934337biostudies-literatureThe surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.PMC12934337Hwang SHChoi JHKim JHur JYWon YWLee JHfalseThe surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.<h4>Background</h4>The treatment strategy for intestinal non-Hodgkin lymphoma (NHL) and the role of surgery warrant reevaluation.<h4>Methods</h4>This study analyzed clinical data from a cohort of 12,047 patients diagnosed with intestinal NHL, extracted from the Korean National Health Insurance System database between 2002 and 2021.<h4>Results</h4>Among these patients, 3,566 (29.6%) were categorized into the surgery group, while 8,481 (70.4%) were included in the nonsurgery group. Surgery was independently associated with both prolonged overall survival (OS) and a favorable prognosis in multivariate analysis (Hazard Ratio [HR] = 0.645, 95% Confidence Interval [CI] = 0.598-0.695, <i>p</i> <.001). The median OS was longer in patients who underwent lymph node dissection during surgery than in patients who did not undergo lymph node dissection (10-year OS with lymph node dissection 63.17% vs. surgery without lymph node dissection 54.78%, <i>p</i> < .001).<h4>Conclusions</h4>To our knowledge, this is the first Korean population-based nationwide study to describe the clinical impact of surgery on the OS of patients with intestinal NHL. A prospective randomized study evaluating strategies to improve the survival of intestinal NHL patients is needed.2026-01-01T00:00:00Z2026 Dec2026-07-10T03:26:20.384Z2026-07-10T03:16:25.896ZS-EPMC129343374173290310.1080/07853890.2026.2634447