{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ellin NR"],"funding":["National Institute of General Medical Sciences"],"pubmed_abstract":["This work summarizes the criteria for a useful reagent for ion/ion proton transfer in an electrodynamic ion trap with specific emphasis on proton transfer to high mass multiply-charged analyte ions. A readily available and ionizable weak base of relatively high mass meets the criteria. The protonated form of an extensively fluorinated 10-carbon primary amine (1<i>H</i>,1<i>H</i>,2<i>H</i>,2<i>H</i>-perfluorodecylamine, PFDA) is demonstrated to serve as a useful reagent for proton transfer to negatively-charged proteins and oligonucleotides. The behavior of protonated PFDA is compared with that of protonated 1,8-bis(dimethylamino)naphthalene (proton sponge) with respect to the tendency for proton transfer <i>versus</i> attachment in ion/ion reactions with a common multiply-deprotonated prot"],"journal":["The Analyst"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12935111"],"repository":["biostudies-literature"],"pubmed_title":["Proton transfer reagent cations for ion-ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap."],"pmcid":["PMC12935111"],"funding_grant_id":["R35-153191"],"pubmed_authors":["McLuckey SA","Faye BKS","Horn SA","Koers AM","Ellin NR"],"additional_accession":[]},"is_claimable":false,"name":"Proton transfer reagent cations for ion-ion charge state manipulation of high mass negatively-charged analytes in an electrodynamic ion trap.","description":"This work summarizes the criteria for a useful reagent for ion/ion proton transfer in an electrodynamic ion trap with specific emphasis on proton transfer to high mass multiply-charged analyte ions. A readily available and ionizable weak base of relatively high mass meets the criteria. The protonated form of an extensively fluorinated 10-carbon primary amine (1<i>H</i>,1<i>H</i>,2<i>H</i>,2<i>H</i>-perfluorodecylamine, PFDA) is demonstrated to serve as a useful reagent for proton transfer to negatively-charged proteins and oligonucleotides. The behavior of protonated PFDA is compared with that of protonated 1,8-bis(dimethylamino)naphthalene (proton sponge) with respect to the tendency for proton transfer <i>versus</i> attachment in ion/ion reactions with a common multiply-deprotonated prot","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T20:47:54.576Z","creation":"2026-07-10T03:13:06.457Z"},"accession":"S-EPMC12935111","cross_references":{"pubmed":["41739648"],"doi":["10.1039/d5an01354b"]}}