{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Cleveland JD"],"funding":["NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Heart Lung and Blood Institute Division of Intramural Research","NIH HHS"],"pubmed_abstract":["Gene-edited pig hearts may have an application for critically ill infants who are poor candidates for mechanical support. We established a pediatric animal model of gene-edited pig orthotopic cardiac xenotransplantation (OCXT) in baboons to assess its potential as a bridge to allotransplantation. Fifteen OCXTs were performed from genetically-engineered infantile pigs into size-matched baboons. Maintenance immunosuppression was founded on CD40/CD154 costimulation pathway blockade and rapamycin. After being sustained by xenografts for >4 months, 3 xenograft recipients were selected for transition to cardiac allotransplantation. Outcomes were tracked by invasive hemodynamic monitoring, surface echocardiography, and serial blood tests. After OCXT, 8 of 15 (53%) baboons achieved survival of >1 "],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pagination":["S1600-6135(25)03182-X"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12935157"],"repository":["biostudies-literature"],"pubmed_title":["Gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants: Progress in a pig-to-baboon model."],"pmcid":["PMC12935157"],"funding_grant_id":["R33 HL163718","P40 OD024628"],"pubmed_authors":["Low S","Moreno I","Cooper DKC","Hodo CL","Katz E","Simmons J","Fenske J","Chitta S","Yeung V","Swicord W","Cleveland DC","Mitchell CB","Vo C","Weisert M","Bakshi K","Juliani J","De La Garza M","Cleveland JD","Getchell K","Neal SJ","Perrin S"],"additional_accession":[]},"is_claimable":false,"name":"Gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants: Progress in a pig-to-baboon model.","description":"Gene-edited pig hearts may have an application for critically ill infants who are poor candidates for mechanical support. We established a pediatric animal model of gene-edited pig orthotopic cardiac xenotransplantation (OCXT) in baboons to assess its potential as a bridge to allotransplantation. Fifteen OCXTs were performed from genetically-engineered infantile pigs into size-matched baboons. Maintenance immunosuppression was founded on CD40/CD154 costimulation pathway blockade and rapamycin. After being sustained by xenografts for >4 months, 3 xenograft recipients were selected for transition to cardiac allotransplantation. Outcomes were tracked by invasive hemodynamic monitoring, surface echocardiography, and serial blood tests. After OCXT, 8 of 15 (53%) baboons achieved survival of >1 ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-10T03:26:02.913Z","creation":"2026-07-10T03:16:20.243Z"},"accession":"S-EPMC12935157","cross_references":{"pubmed":["41453738"],"doi":["10.1016/j.ajt.2025.12.017"]}}