{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kalamara M"],"funding":["Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["e1012050"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12935306"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["Intraspecies interactions shape microbial community structure and evolution, yet the mechanisms determining competitive outcomes among closely related strains remain unclear. The soil bacterium Bacillus subtilis is a model for microbial social interactions, where quorum-sensing systems regulate cooperation and antagonism. Here, we take a multifaceted approach to dissect the role of quorum-sensing regulation in competitive fitness. Isolate NCIB 3610 carries a signal unresponsive RapP-PhrP module that alters quorum-sensing control and promotes faster growth. Modelling and mutant analysis demonstrate that the small differences in growth rate conferred by RapP-PhrP3610 are sufficient to drive competitive exclusion. The importance of quorum sensing control is further exemplified by experimental"],"journal":["PLoS genetics"],"pubmed_title":["Regulatory rewiring drives intraspecies competition in Bacillus subtilis."],"pmcid":["PMC12935306"],"funding_grant_id":["BB/M010996/1","BB/R012415/1","225350/Z/22/Z","BB/X002950/1","BB/Z516600/1","218520/Z/19/Z","BB/P001335/1"],"pubmed_authors":["Griffin J","Kalamara M","Bonsall A","Wood A","Stevenson D","Gierlinski M","Carneiro J","Dorfmueller HC","Porter M","Stanley-Wall NR","Eigentler L","MacPhee CE","Abbott JC"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory rewiring drives intraspecies competition in Bacillus subtilis.","description":"Intraspecies interactions shape microbial community structure and evolution, yet the mechanisms determining competitive outcomes among closely related strains remain unclear. The soil bacterium Bacillus subtilis is a model for microbial social interactions, where quorum-sensing systems regulate cooperation and antagonism. Here, we take a multifaceted approach to dissect the role of quorum-sensing regulation in competitive fitness. Isolate NCIB 3610 carries a signal unresponsive RapP-PhrP module that alters quorum-sensing control and promotes faster growth. Modelling and mutant analysis demonstrate that the small differences in growth rate conferred by RapP-PhrP3610 are sufficient to drive competitive exclusion. The importance of quorum sensing control is further exemplified by experimental","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T21:34:03.769Z","creation":"2026-07-12T03:08:28.888Z"},"accession":"S-EPMC12935306","cross_references":{"pubmed":["41701782"],"doi":["10.1371/journal.pgen.1012050"]}}