biostudies-literatureLee DNational Institute of Biological ResourcesMinistry of Science and ICT, South KoreaNational Research Foundation of KoreaMinistry of Environmente2601015https://www.ebi.ac.uk/biostudies/studies/S-EPMC12935503biostudies-literatureUnknown36Halophilic archaea are extremophilic microorganisms uniquely adapted to thrive in hypersaline environments such as solar salterns, saline lakes, and brines. Their ability to survive under high-salt conditions is closely associated with the production of unique compounds specifically synthesized by haloarchaea, including bacterioruberin and halorhodopsin. Bacterioruberin is a carotenoid pigment that protects cells from oxidative stress and contributes to osmotic stress resistance. Halorhodopsin is a light-driven Cl^- pump that helps maintain ionic homeostasis. These functional molecules play crucial roles in osmotic stress resistance and energy conversion under extreme conditions. Therefore, understanding their genomic information is essential to uncover the molecular mechanisms uJournal of microbiology and biotechnologyGenomic Insights into Bacterioruberin and Halorhodopsin Biosynthetic Genes in 12 Halophilic Archaea Isolated from Korean Solar Salterns.PMC12935503RS-2025-16067759NIBR202405101RS-2025-00554776You YHSeo MJCho ESHwang CYLee DfalseGenomic Insights into Bacterioruberin and Halorhodopsin Biosynthetic Genes in 12 Halophilic Archaea Isolated from Korean Solar Salterns.Halophilic archaea are extremophilic microorganisms uniquely adapted to thrive in hypersaline environments such as solar salterns, saline lakes, and brines. Their ability to survive under high-salt conditions is closely associated with the production of unique compounds specifically synthesized by haloarchaea, including bacterioruberin and halorhodopsin. Bacterioruberin is a carotenoid pigment that protects cells from oxidative stress and contributes to osmotic stress resistance. Halorhodopsin is a light-driven Cl^- pump that helps maintain ionic homeostasis. These functional molecules play crucial roles in osmotic stress resistance and energy conversion under extreme conditions. Therefore, understanding their genomic information is essential to uncover the molecular mechanisms u2026-01-01T00:00:00Z2026 Feb2026-07-16T21:32:42.425Z2026-07-10T03:16:27.363ZS-EPMC129355034166845510.4014/jmb.2601.01015