biostudies-literatureBorrego-Yaniz GMinisterio de Ciencia, Tecnología e InnovaciónFoundation for Research in Rheumatology385-393https://www.ebi.ac.uk/biostudies/studies/S-EPMC12936897biostudies-literatureUnknown78(2)<h4>Objective</h4>Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the arterial tissue of patients with this vasculitis.<h4>Methods</h4>DNA methylation profiling was analyzed in 79 temporal artery biopsy samples (69 patients with GCA and 10 controls) by performing an epigenome-wide association study (EWAS). Differential analysis was performed to identify differentially methylated positions (DMPs) and differentially methylated regions (DMRs). Lastly, we compared our findings with previous transcriptomics and epigenomics studies on GCA-affected arteries.<h4>Results</h4>EWAS identified 3,644 DMPs (P<sub>adjArthritis & rheumatology (Hoboken, N.J.)Genome-Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis.PMC12936897RYC2022-036635-IPREP2022-000712Lio PSalvarani CEstupinan-Moreno EGuggino GMuratore FCavazza APipitone NCastaneda SSaadoun DBonacini MCroci SGonzalez-Gay MATerron-Camero LCMartin JBorrego-Yaniz GMarquez AFontana SOrtiz-Fernandez LRossi AfalseGenome-Wide DNA Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis.<h4>Objective</h4>Giant cell arteritis (GCA) is a large-vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the arterial tissue of patients with this vasculitis.<h4>Methods</h4>DNA methylation profiling was analyzed in 79 temporal artery biopsy samples (69 patients with GCA and 10 controls) by performing an epigenome-wide association study (EWAS). Differential analysis was performed to identify differentially methylated positions (DMPs) and differentially methylated regions (DMRs). Lastly, we compared our findings with previous transcriptomics and epigenomics studies on GCA-affected arteries.<h4>Results</h4>EWAS identified 3,644 DMPs (P<sub>adj2026-01-01T00:00:00Z2026 Feb2026-07-16T22:06:43.161Z2026-07-11T03:12:04.312ZS-EPMC129368974082698010.1002/art.43358