{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["78(2)"],"submitter":["Yang MM"],"funding":["Rheumatology Research Foundation","Scleroderma Research Foundation"],"pubmed_abstract":["<h4>Objective</h4>Peripheral blood leukocyte telomere length (PBL-TL) shortening is associated with systemic sclerosis-related interstitial lung disease (SSc-ILD). However, its association with other organ involvement, disease severity, and survival remains unclear. This study aimed to define the relationship of TL with SSc-specific disease manifestations and outcomes.<h4>Methods</h4>PBL-TL was measured by quantitative polymerase chain reaction in 244 patients with SSc and 314 healthy controls. Multivariate modeling was used to assess the association of PBL-TL with disease severity and event-free survival. Longitudinal changes in PBL-TL were measured in a subset of patients. TL was quantified in SSc skin and lung tissues by telomere fluorescence in situ hybridization.<h4>Results</h4>PBL-TL"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pagination":["428-437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12936899"],"repository":["biostudies-literature"],"pubmed_title":["Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis."],"pmcid":["PMC12936899"],"pubmed_authors":["Yang MM","Lee S","French S","Boin F","Liu S","Wax M","Wolters PJ"],"additional_accession":[]},"is_claimable":false,"name":"Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis.","description":"<h4>Objective</h4>Peripheral blood leukocyte telomere length (PBL-TL) shortening is associated with systemic sclerosis-related interstitial lung disease (SSc-ILD). However, its association with other organ involvement, disease severity, and survival remains unclear. This study aimed to define the relationship of TL with SSc-specific disease manifestations and outcomes.<h4>Methods</h4>PBL-TL was measured by quantitative polymerase chain reaction in 244 patients with SSc and 314 healthy controls. Multivariate modeling was used to assess the association of PBL-TL with disease severity and event-free survival. Longitudinal changes in PBL-TL were measured in a subset of patients. TL was quantified in SSc skin and lung tissues by telomere fluorescence in situ hybridization.<h4>Results</h4>PBL-TL","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T21:58:15.553Z","creation":"2026-07-11T03:08:46.124Z"},"accession":"S-EPMC12936899","cross_references":{"pubmed":["40964771"],"doi":["10.1002/art.43400"]}}