biostudies-literatureHaque RCalifornia Breast Cancer Research Programe71642https://www.ebi.ac.uk/biostudies/studies/S-EPMC12936983biostudies-literatureUnknown15(3)<h4>Background</h4>Although nearly half of women with metastatic breast cancer (mBC) have hypertension, it is unclear whether hypertension management improves survival. We examined the influence of pharmacologic hypertension management on all-cause and breast cancer-specific mortality in patients with mBC.<h4>Methods</h4>We conducted a longitudinal cohort study of 1332 female patients with de novo mBC diagnosed 2008-2020, followed through 2021. We calculated person-year (PY) rates of all-cause and breast cancer mortality by use of antihypertensives (monotherapy or polytherapy [one vs. multiple drug classes]). Multivariable Cox regression was used to estimate the association between antihypertensives and mortality.<h4>Results</h4>Overall, 48.4% of patients with mBC had hypertension, which wCancer medicineInfluence of Hypertension Management on Survival in Patients With Metastatic Breast Cancer.PMC12936983B28TR5470Barac AHogan TASilverman AChen LHBrady-Rogers MGu ZMukherjee AHaque RWallner LPfalseInfluence of Hypertension Management on Survival in Patients With Metastatic Breast Cancer.<h4>Background</h4>Although nearly half of women with metastatic breast cancer (mBC) have hypertension, it is unclear whether hypertension management improves survival. We examined the influence of pharmacologic hypertension management on all-cause and breast cancer-specific mortality in patients with mBC.<h4>Methods</h4>We conducted a longitudinal cohort study of 1332 female patients with de novo mBC diagnosed 2008-2020, followed through 2021. We calculated person-year (PY) rates of all-cause and breast cancer mortality by use of antihypertensives (monotherapy or polytherapy [one vs. multiple drug classes]). Multivariable Cox regression was used to estimate the association between antihypertensives and mortality.<h4>Results</h4>Overall, 48.4% of patients with mBC had hypertension, which w2026-01-01T00:00:00Z2026 Mar2026-07-16T21:55:12.622Z2026-07-12T03:07:28.554ZS-EPMC129369834174423410.1002/cam4.71642