{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matjan Stefin P"],"funding":["The Slovenian Research and Innovation Agency"],"pagination":["360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12939340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["<b>Background/Objectives</b>: Cysteine cathepsins and their endogenous inhibitors have been shown to possess context-dependent functions in cancer progression, including the regulation of tumor metabolic pathways. Stefin B and cystatin C, intracellular and extracellular protease inhibitors, respectively, can modulate tumor biology through protease-dependent and protease-independent mechanisms. This study investigated their combined functions and potential roles as tumor promoters in breast cancer in a spontaneous breast cancer mouse model (PyMT mice). <b>Methods</b>: We generated PyMT transgenic mice lacking both stefin B and cystatin C (double-knockout, DKO) and compared their tumor growth kinetics, proliferation, apoptosis, and metastatic burden with those of wild-type control mice. Immu"],"journal":["Cells"],"pubmed_title":["Stefin B and Cystatin C Deficiency Suppresses Tumor Growth and Alters Tumor Microenvironment in a Breast Cancer Model."],"pmcid":["PMC12939340"],"funding_grant_id":["P1-0140"],"pubmed_authors":["Turk B","Mikhaylov G","Matjan Stefin P","Zavrsnik J","Vasiljeva O","Butinar M"],"additional_accession":[]},"is_claimable":false,"name":"Stefin B and Cystatin C Deficiency Suppresses Tumor Growth and Alters Tumor Microenvironment in a Breast Cancer Model.","description":"<b>Background/Objectives</b>: Cysteine cathepsins and their endogenous inhibitors have been shown to possess context-dependent functions in cancer progression, including the regulation of tumor metabolic pathways. Stefin B and cystatin C, intracellular and extracellular protease inhibitors, respectively, can modulate tumor biology through protease-dependent and protease-independent mechanisms. This study investigated their combined functions and potential roles as tumor promoters in breast cancer in a spontaneous breast cancer mouse model (PyMT mice). <b>Methods</b>: We generated PyMT transgenic mice lacking both stefin B and cystatin C (double-knockout, DKO) and compared their tumor growth kinetics, proliferation, apoptosis, and metastatic burden with those of wild-type control mice. Immu","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-11T03:19:07.373Z","creation":"2026-07-11T03:09:48.53Z"},"accession":"S-EPMC12939340","cross_references":{"pubmed":["41744803"],"doi":["10.3390/cells15040360"]}}