{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bayat T"],"funding":["Empirical Foods Inc.","Foundation for Prader-Willi Syndrome Research","Texas Tech University start-up","TTUAB Grants-in-Aid","Texas Tech University School of Veterinary Medicine Seed award","Texas Center for Comparative Cancer Research","Cancer Prevention and Research Institute of Texas"],"pagination":["139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12939545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(2)"],"pubmed_abstract":["Melanoma-associated antigens (MAGEs) are cancer-testis antigens (CTAs) aberrantly expressed in multiple cancer types, including hepatocellular carcinoma (HCC), and associated with aggressive phenotypes. Although MAGE proteins are widely studied as cancer immunotherapy targets, their roles in HCC and the regulation of their expression during liver pathogenesis in mouse models, including dietary effects, remain poorly understood. We analyzed <i>Mage</i> gene expression in liver tissues from 78 C3H/HeJ mice with chronic diet-induced obesity. While type I <i>MAGE</i> genes are frequently expressed in human HCC, we found no evidence of their expression in mouse liver tumors, suggesting species-specific regulation. In contrast, type II <i>Maged2</i>, previously reported to be upregulated in huma"],"journal":["Current issues in molecular biology"],"pubmed_title":["Cross-Species Upregulation of &lt;i&gt;MAGED2&lt;/i&gt; in Liver Cancer Suggests a Role in Obesity-Driven Tumor Progression."],"pmcid":["PMC12939545"],"funding_grant_id":["NA","A18-0187","22-0321 and 23-0447","RR200059"],"pubmed_authors":["Olayiwola Y","Gollahon L","Barr B","Rozman D","Fon Tacer K","Myers S","Popy FY","Gutierrez JSS","Stepihar D","Blagotinsek Cokan K","Bayat T","Gee RRF","Diaz-Riano J"],"additional_accession":[]},"is_claimable":false,"name":"Cross-Species Upregulation of &lt;i&gt;MAGED2&lt;/i&gt; in Liver Cancer Suggests a Role in Obesity-Driven Tumor Progression.","description":"Melanoma-associated antigens (MAGEs) are cancer-testis antigens (CTAs) aberrantly expressed in multiple cancer types, including hepatocellular carcinoma (HCC), and associated with aggressive phenotypes. Although MAGE proteins are widely studied as cancer immunotherapy targets, their roles in HCC and the regulation of their expression during liver pathogenesis in mouse models, including dietary effects, remain poorly understood. We analyzed <i>Mage</i> gene expression in liver tissues from 78 C3H/HeJ mice with chronic diet-induced obesity. While type I <i>MAGE</i> genes are frequently expressed in human HCC, we found no evidence of their expression in mouse liver tumors, suggesting species-specific regulation. In contrast, type II <i>Maged2</i>, previously reported to be upregulated in huma","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-11T03:15:31.884Z","creation":"2026-07-11T03:11:56.041Z"},"accession":"S-EPMC12939545","cross_references":{"pubmed":["41751403"],"doi":["10.3390/cimb48020139"]}}