biostudies-literatureCall CU.S. Department of Health &amp; Human Services | NIH | National Institute of Neurological Disorders and StrokeU.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)NINDS NIH HHSU.S. Department of Health &amp; Human Services | NIH | NIH Office of the DirectorNIH HHSU.S. Department of Health & Human Services | NIH | NIH Office of the Director (OD)835-843https://www.ebi.ac.uk/biostudies/studies/S-EPMC12943005biostudies-literatureUnknown44(6)<h4>Objective</h4>To evaluate the association between prenatal maternal health and socioeconomic status (SES) and health-related quality of life (QoL) among 10-year-old children born extremely preterm.<h4>Design/ methods</h4>Retrospective analysis of the Extremely Low Gestational Age Newborns (ELGAN) Study cohort of infants born < 28 weeks gestational age. QoL was assessed at 10 years of age using the Pediatric Quality of Life Inventory. Multivariate regression models were used for analyses.<h4>Results</h4>Of 1198 participants who survived until 10 years of age, 889 (72.2%) were evaluated. Lower maternal age, lack of college education; receipt of public insurance and Supplemental Nutrition Assistance Program (SNAP) were associated with lower QoL scores. Specific maternal health factors were also associated with lower child QoL scores.<h4>Conclusions</h4>Specific, potentially modifiable, maternal health and social factors are associated with lower scores on a measure of parent-reported child QoL across multiple domains for children born extremely preterm.Journal of perinatology : official journal of the California Perinatal AssociationHealth-related quality of life at age 10 years in children born extremely preterm.PMC12943005U01 NS0400692R01NS040069-09UH3 OD0233481UG3OD023348-015U01NS040069-05Shenberger JVaidya RJensen ETMsall MEFrazier JAKim SOran AO'Shea TMFry RCGogcu SSingh RJalnapurkar ICall CfalseHealth-related quality of life at age 10 years in children born extremely preterm.<h4>Objective</h4>To evaluate the association between prenatal maternal health and socioeconomic status (SES) and health-related quality of life (QoL) among 10-year-old children born extremely preterm.<h4>Design/ methods</h4>Retrospective analysis of the Extremely Low Gestational Age Newborns (ELGAN) Study cohort of infants born < 28 weeks gestational age. QoL was assessed at 10 years of age using the Pediatric Quality of Life Inventory. Multivariate regression models were used for analyses.<h4>Results</h4>Of 1198 participants who survived until 10 years of age, 889 (72.2%) were evaluated. Lower maternal age, lack of college education; receipt of public insurance and Supplemental Nutrition Assistance Program (SNAP) were associated with lower QoL scores. Specific maternal health factors were also associated with lower child QoL scores.<h4>Conclusions</h4>Specific, potentially modifiable, maternal health and social factors are associated with lower scores on a measure of parent-reported child QoL across multiple domains for children born extremely preterm.2024-01-01T00:00:00Z2024 Jun2026-07-11T03:11:32.014Z2026-07-11T03:09:13.105ZS-EPMC129430053876057910.1038/s41372-024-01987-3