biostudies-literatureKing-Dowling SChildren&apos;s Hospital of PhiladelphiaAlex&apos;s Lemonade Stand Foundation for Childhood CancerNational Institute of Nursing ResearchNational Cancer InstituteOncology Nursing Society FoundationNCI NIH HHSe30291https://www.ebi.ac.uk/biostudies/studies/S-EPMC12944686biostudies-literatureUnknown70(6)<h4>Background</h4>Caregivers and adolescents and young adult (AYA) cancer survivors may be at greater psychosocial risk from the COVID-19 pandemic than healthy peers due to complex and traumatic medical histories. This study describes COVID-19-related event exposures, impact, and distress among a large sample of caregivers and AYA cancer survivors and the relationship of these variables to demographic and cancer characteristics.<h4>Procedure</h4>From May 2020 to December 2021, 422 caregivers and 531 AYA survivors completed the COVID-19 Exposures and Family Impact Survey (CEFIS) and CEFIS-AYA, respectively. Total COVID-19-related exposures, average COVID-19-related impact, and COVID-19-related distress were calculated. Conventional content analysis was used to analyze free-text responses aPediatric blood & cancerPsychosocial impact of COVID-19 on caregivers and adolescents and young adult survivors of childhood cancer.PMC12944686K08 CA241335Faust HDeatrick JAMadden RHammer SNKing-Dowling SPai AAlbee MDaniel LBarakat LPPsihogios AMDrake SAhmed ASchwartz LAFreyer DfalsePsychosocial impact of COVID-19 on caregivers and adolescents and young adult survivors of childhood cancer.<h4>Background</h4>Caregivers and adolescents and young adult (AYA) cancer survivors may be at greater psychosocial risk from the COVID-19 pandemic than healthy peers due to complex and traumatic medical histories. This study describes COVID-19-related event exposures, impact, and distress among a large sample of caregivers and AYA cancer survivors and the relationship of these variables to demographic and cancer characteristics.<h4>Procedure</h4>From May 2020 to December 2021, 422 caregivers and 531 AYA survivors completed the COVID-19 Exposures and Family Impact Survey (CEFIS) and CEFIS-AYA, respectively. Total COVID-19-related exposures, average COVID-19-related impact, and COVID-19-related distress were calculated. Conventional content analysis was used to analyze free-text responses a2023-01-01T00:00:00Z2023 Jun2026-07-16T21:55:25.818Z2026-07-10T03:15:30.69ZS-EPMC129446863695141310.1002/pbc.30291