{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vo TK"],"funding":["AMED Japan Program for Infectious Diseases Research and Infrastructure","Nagase Science Technology Foundation","Naito Foundation","Takeda Foundation","Kaketsuken Foundation","Ministry of Education, Culture, Sports, Science and Technology of Japan"],"pagination":["e1013940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12944779"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["Entamoeba histolytica, a protozoan parasite, causes amebiasis. Amebiasis is mainly transmitted by oral ingestion of cysts. Cysts are produced in the large intestine of humans from proliferative trophozoites by a cell differentiation process called encystation. The Entamoeba cyst wall consists of chitins and proteins that include chitinase and Jacob and Jessie lectins. During encystation, these components are synthesized and layered around encysting Entamoeba cells. The structures of these components are well studied; however, the detailed timings of their synthesis (the transcription of the encoding genes and the translation of the resulting mRNAs) and of changes in their localization during encystation are poorly understood. Here, we performed quantitative RT-PCR and an approach combining"],"journal":["PLoS pathogens"],"pubmed_title":["Trafficking and organization of cyst wall components into a robust biphasic structure in Entamoeba."],"pmcid":["PMC12944779"],"funding_grant_id":["18H04675, 21K06992 and 25K02488","23wm0325036 and 25wm0325071","24K23322","19K07627 and 24K10273"],"pubmed_authors":["Vo TK","Yoshida H","Mi-Ichi F"],"additional_accession":[]},"is_claimable":false,"name":"Trafficking and organization of cyst wall components into a robust biphasic structure in Entamoeba.","description":"Entamoeba histolytica, a protozoan parasite, causes amebiasis. Amebiasis is mainly transmitted by oral ingestion of cysts. Cysts are produced in the large intestine of humans from proliferative trophozoites by a cell differentiation process called encystation. The Entamoeba cyst wall consists of chitins and proteins that include chitinase and Jacob and Jessie lectins. During encystation, these components are synthesized and layered around encysting Entamoeba cells. The structures of these components are well studied; however, the detailed timings of their synthesis (the transcription of the encoding genes and the translation of the resulting mRNAs) and of changes in their localization during encystation are poorly understood. Here, we performed quantitative RT-PCR and an approach combining","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:00:56.867Z","creation":"2026-07-11T03:09:05.485Z"},"accession":"S-EPMC12944779","cross_references":{"pubmed":["41746876"],"doi":["10.1371/journal.ppat.1013940"]}}