biostudies-literatureUnknown11(2)Lampazzi EThe Incompatible Insect Technique (IIT) is a species-specific, eco-friendly mosquito control method that relies on releasing <i>Wolbachia</i>-infected males, which induce cytoplasmic incompatibility (CI), rendering eggs inviable when mating with wild females. Aiming at optimizing IIT protocols in terms of cost-effectiveness, data on incompatible male dispersal and survival and the distance- and time-related impact of induced sterility are fundamental. This study plans to fill this gap and reports findings from a two-year field trial (2022-2023) at the ENEA-Casaccia Research Center, based on single-spot releases of incompatible <i>Aedes albopictus</i> males (AR<i>w</i>P strain). Male releases were carried out in late September 2022 (~15,000 released males) and the early <i>Ae. albopictus</iTropical medicine and infectious disease45https://www.ebi.ac.uk/biostudies/studies/S-EPMC12944944biostudies-literatureSpatial Dynamics and Sterilization Range of Incompatible &lt;i&gt;Aedes albopictus&lt;/i&gt; Males: Advancing Toward an Optimized IIT Approach.PMC12944944Caputo BMoretti RSantarelli GVirgillito CLombardi GLampazzi ECalvitti MfalseSpatial Dynamics and Sterilization Range of Incompatible &lt;i&gt;Aedes albopictus&lt;/i&gt; Males: Advancing Toward an Optimized IIT Approach.The Incompatible Insect Technique (IIT) is a species-specific, eco-friendly mosquito control method that relies on releasing <i>Wolbachia</i>-infected males, which induce cytoplasmic incompatibility (CI), rendering eggs inviable when mating with wild females. Aiming at optimizing IIT protocols in terms of cost-effectiveness, data on incompatible male dispersal and survival and the distance- and time-related impact of induced sterility are fundamental. This study plans to fill this gap and reports findings from a two-year field trial (2022-2023) at the ENEA-Casaccia Research Center, based on single-spot releases of incompatible <i>Aedes albopictus</i> males (AR<i>w</i>P strain). Male releases were carried out in late September 2022 (~15,000 released males) and the early <i>Ae. albopictus</i2026-01-01T00:00:00Z2026 Feb2026-07-10T03:24:13.835Z2026-07-10T03:16:40.92ZS-EPMC129449444174601510.3390/tropicalmed11020045