{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu Y"],"funding":["National Key Research and Development Programs of China"],"pagination":["102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12944946"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Zearalenone (ZEA) is a prevalent non-steroidal estrogenic mycotoxin in feed and feedstuffs. This study investigated the effects of graded dietary purified ZEA standard (0, 0.2, 0.5, 1, 2, and 4 mg/kg) on growth performance, blood biochemistry, oxidative stress, immune response, intestinal morphology, histopathology, and gut microbiota in broilers. The use of purified ZEA standard eliminates confounding effects from co-occurring contaminants and the reduced nutritional quality of naturally contaminated feed, allowing an accurate assessment of ZEA-specific effects. A total of 216 one-day-old Arbor Acres male broilers were randomly allocated into six treatment groups, each with six replicates of six birds, for a 42-day trial. At the regulatory limit (0.5 mg/kg) and below, no overt toxic effec"],"journal":["Toxins"],"pubmed_title":["Purified Zearalenone at the Regulatory Limit Exhibits No Overt Toxicity in Broilers."],"pmcid":["PMC12944946"],"funding_grant_id":["2023YFD1301002"],"pubmed_authors":["Zhang W","Liu Y","Yang W","He W","Duan Q","Chen Y","Luo S","Nie W"],"additional_accession":[]},"is_claimable":false,"name":"Purified Zearalenone at the Regulatory Limit Exhibits No Overt Toxicity in Broilers.","description":"Zearalenone (ZEA) is a prevalent non-steroidal estrogenic mycotoxin in feed and feedstuffs. This study investigated the effects of graded dietary purified ZEA standard (0, 0.2, 0.5, 1, 2, and 4 mg/kg) on growth performance, blood biochemistry, oxidative stress, immune response, intestinal morphology, histopathology, and gut microbiota in broilers. The use of purified ZEA standard eliminates confounding effects from co-occurring contaminants and the reduced nutritional quality of naturally contaminated feed, allowing an accurate assessment of ZEA-specific effects. A total of 216 one-day-old Arbor Acres male broilers were randomly allocated into six treatment groups, each with six replicates of six birds, for a 42-day trial. At the regulatory limit (0.5 mg/kg) and below, no overt toxic effec","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-10T03:20:45.799Z","creation":"2026-07-10T03:15:43.368Z"},"accession":"S-EPMC12944946","cross_references":{"pubmed":["41745768"],"doi":["10.3390/toxins18020102"]}}