{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma R"],"funding":["Niu Qiang"],"pagination":["128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12944959"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Excessive fluoride exposure induces developmental neurotoxicity, but effective preventive strategies are currently scarce. Melatonin (Mel), a lipophilic hormone secreted by the pineal gland, exerts antioxidant, anti-inflammatory, and neuroprotective properties. This study aimed to explore Mel's protective effect and mechanism against fluoride-induced developmental brain injury. We employed a network pharmacology approach to screen the common targets of Mel and fluoride-induced brain injury and performed enrichment analysis. A total of 189 common targets were identified, and these targets were mainly enriched in the HIF-1 signaling pathway and oxidative stress-related pathways. In vivo, Sprague Dawley rats were subjected to perinatal sodium fluoride (NaF) exposure with/without Mel; in vitro"],"journal":["Toxics"],"pubmed_title":["Combining Network Pharmacology and Experimental Verification to Investigate the Protective Effect of Melatonin on Fluoride-Induced Brain Injury."],"pmcid":["PMC12944959"],"funding_grant_id":["the Science and Technology Program of XPCC (Grant Nos. 2025DB010 and 2024ZD025), the grants from the National Natural Science Foundation of China (Grant No. 82360671), the Shihezi University International Science and Technology Cooperation Promotion Progr"],"pubmed_authors":["Ma R","Li Y","Xie G","Wang C","Liang Y","Wang S","Niu Q","Zhang M","Qin W","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Combining Network Pharmacology and Experimental Verification to Investigate the Protective Effect of Melatonin on Fluoride-Induced Brain Injury.","description":"Excessive fluoride exposure induces developmental neurotoxicity, but effective preventive strategies are currently scarce. Melatonin (Mel), a lipophilic hormone secreted by the pineal gland, exerts antioxidant, anti-inflammatory, and neuroprotective properties. This study aimed to explore Mel's protective effect and mechanism against fluoride-induced developmental brain injury. We employed a network pharmacology approach to screen the common targets of Mel and fluoride-induced brain injury and performed enrichment analysis. A total of 189 common targets were identified, and these targets were mainly enriched in the HIF-1 signaling pathway and oxidative stress-related pathways. In vivo, Sprague Dawley rats were subjected to perinatal sodium fluoride (NaF) exposure with/without Mel; in vitro","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-11T03:15:09.926Z","creation":"2026-07-11T03:11:31.74Z"},"accession":"S-EPMC12944959","cross_references":{"pubmed":["41745802"],"doi":["10.3390/toxics14020128"]}}