{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zeng Y"],"funding":["Beijing Hospitals Authority Ascent Plan","Research Foundation of Capital Institute of Pediatrics","American Chinese Medical Foundation","High-level Public Health Talents Training Plan"],"pagination":["149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12945083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["<h4>Background</h4>Children with special healthcare needs (CSHCNs) face persistent barriers to timely immunization in China, but comparative evidence across disease groups and vaccines, and data on immune function, are limited.<h4>Methods</h4>We conducted a retrospective cohort study linking electronic medical records, vaccination records, and a structured telephone and questionnaire follow-up. We estimated timely vaccination by National Immunization Program (NIP) dose definitions, assessed catch-up completion at follow-up, and compared cellular/humoral/complement immune indices with published pediatric reference ranges. Group differences used ANOVA/Kruskal-Wallis and chi-square (χ<sup>2</sup>)/Fisher's exact tests with Bonferroni correction.<h4>Results</h4>Timely vaccination was lower tha"],"journal":["Vaccines"],"pubmed_title":["Timeliness of Routine Vaccination, Catch-Up Completion, and Immune Function in Chinese Children with Special Healthcare Needs: A Retrospective Cohort Study."],"pmcid":["PMC12945083"],"funding_grant_id":["LCYJ-2025-02 to Yu Tian","AL-02-19","21-433","DFL20221103"],"pubmed_authors":["Li X","Liu Y","An Q","Huang Y","Tian Y","Zhou B","Zeng Y","Zhang L","Wang J","Yang C","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Timeliness of Routine Vaccination, Catch-Up Completion, and Immune Function in Chinese Children with Special Healthcare Needs: A Retrospective Cohort Study.","description":"<h4>Background</h4>Children with special healthcare needs (CSHCNs) face persistent barriers to timely immunization in China, but comparative evidence across disease groups and vaccines, and data on immune function, are limited.<h4>Methods</h4>We conducted a retrospective cohort study linking electronic medical records, vaccination records, and a structured telephone and questionnaire follow-up. We estimated timely vaccination by National Immunization Program (NIP) dose definitions, assessed catch-up completion at follow-up, and compared cellular/humoral/complement immune indices with published pediatric reference ranges. Group differences used ANOVA/Kruskal-Wallis and chi-square (χ<sup>2</sup>)/Fisher's exact tests with Bonferroni correction.<h4>Results</h4>Timely vaccination was lower tha","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-11T03:14:38.053Z","creation":"2026-07-11T03:11:47.929Z"},"accession":"S-EPMC12945083","cross_references":{"pubmed":["41746070"],"doi":["10.3390/vaccines14020149"]}}