{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Park YJ"],"funding":["Howard Hughes Medical Institute","NIAID NIH HHS","NIH HHS"],"pagination":["619-627"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12945441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["378(6620)"],"pubmed_abstract":["Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies hav"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Imprinted antibody responses against SARS-CoV-2 Omicron sublineages."],"pmcid":["PMC12945441"],"funding_grant_id":["S10 OD023476","DP1 AI158186","R01 AI163019","75N93022C00036"],"pubmed_authors":["Rajesh A","Franko NM","Montiel-Ruiz M","Guarino B","Giannini O","di Iulio J","Abdelnabi R","Ceschi A","Schnell G","Park YJ","Corti D","Soriaga L","Sprouse KR","Stewart C","Addetia A","Bowen JE","Benigni F","Bassi J","Ferrari P","Logue JK","Schmid MA","Pizzuto MS","Noack J","Whelan SPJ","De Marco A","Dang HV","Hauser K","Neyts J","Pinto D","Lanzavecchia A","Piccoli L","Bourhy H","Virgin HW","Rivera W","Silacci-Fregni C","Kergoat L","Farhat N","Kaiser H","de Melo GD","Liu Z","Janer J","Zhou J","Chu HY","Purcell LA","Veesler D","Lempp FA","Walls AC","Snell G","Zatta F","Saliba C","Maes P","Giurdanella M"],"additional_accession":[]},"is_claimable":false,"name":"Imprinted antibody responses against SARS-CoV-2 Omicron sublineages.","description":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after infection. Although most clinical antibodies hav","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-07-16T21:53:59Z","creation":"2026-07-10T03:15:40.52Z"},"accession":"S-EPMC12945441","cross_references":{"pubmed":["36264829"],"doi":["10.1126/science.adc9127"]}}