biostudies-literatureBikdeli BAmerican Heart Association-American Stroke AssociationAmerican Heart Association Inc556-564https://www.ebi.ac.uk/biostudies/studies/S-EPMC12945443biostudies-literatureUnknown23(2)<h4>Background</h4>Many research investigations for pulmonary embolism (PE) rely on the International Classification of Diseases 10th Revision (ICD-10) codes for analyses of electronic databases. The validity of ICD-10 codes in identifying PE remains uncertain.<h4>Objectives</h4>The objective of this study was to validate an algorithm to efficiently identify pulmonary embolism using ICD-10 codes.<h4>Methods</h4>Using a prespecified protocol, patients in the Mass General-Brigham hospitals (2016-2021) with ICD-10 principal discharge codes for PE, those with secondary codes for PE, and those without PE codes were identified (n = 578 from each group). Weighting was applied to represent each group proportionate to their true prevalence. The accuracy of ICD-10 codes for identifying PE was comparJournal of thrombosis and haemostasis : JTHValidating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism.PMC12945443938814Mojibian HBarco SMahajan SBejjani ALo YCLu YKhera RKrumholz HMAneja SLin ZGoldhaber SZAghayev AWang LKlok FAKrishnathasan DZarghami MRashedi SSecemsky EAAppah-Sampong AMonreal MJimenez JVHunsaker ARCaraballo CZhou LPE-EHR+ InvestigatorsPiazza GBikdeli BJimenez DMuriel AKhairani CDKonstantinides SHussain MAfalseValidating International Classification of Diseases Code 10th Revision algorithms for accurate identification of pulmonary embolism.<h4>Background</h4>Many research investigations for pulmonary embolism (PE) rely on the International Classification of Diseases 10th Revision (ICD-10) codes for analyses of electronic databases. The validity of ICD-10 codes in identifying PE remains uncertain.<h4>Objectives</h4>The objective of this study was to validate an algorithm to efficiently identify pulmonary embolism using ICD-10 codes.<h4>Methods</h4>Using a prespecified protocol, patients in the Mass General-Brigham hospitals (2016-2021) with ICD-10 principal discharge codes for PE, those with secondary codes for PE, and those without PE codes were identified (n = 578 from each group). Weighting was applied to represent each group proportionate to their true prevalence. The accuracy of ICD-10 codes for identifying PE was compar2025-01-01T00:00:00Z2025 Feb2026-07-16T22:06:23.475Z2026-07-11T03:11:39.44ZS-EPMC129454433950515310.1016/j.jtha.2024.10.013