{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(4)"],"submitter":["Wan Mohd Zawawi WFA"],"funding":["Universiti Teknologi Malaysia"],"pubmed_abstract":["Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often employed to improve treatment efficacy and reduce the risk of recurrence. Hyperthermia (HT), a minimally invasive treatment, has shown potential to enhance immunotherapy outcomes. In the EMT6 breast tumor model, elevated CD200 expression is associated with tumor progression, and blockade of the CD200/CD200R signaling pathway has been reported to enhance anti-tumor immune responses. This study presents a preliminary evaluation of the therapeutic effects of local HT combined with anti-CD200 blockade in a preclinical mouse model. EMT6 tumors were established in Balb/c mice via subcutaneous inoculation. Local HT was applied on days 7, 8, and 9 post-inoculation, and anti-CD2"],"journal":["Medical oncology (Northwood, London, England)"],"pagination":["160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12945981"],"repository":["biostudies-literature"],"pubmed_title":["Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model."],"pmcid":["PMC12945981"],"pubmed_authors":["Loh KM","Mohd Salim MI","Abdul Wahab A","Jemon K","Wan Mohd Zawawi WFA"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model.","description":"Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often employed to improve treatment efficacy and reduce the risk of recurrence. Hyperthermia (HT), a minimally invasive treatment, has shown potential to enhance immunotherapy outcomes. In the EMT6 breast tumor model, elevated CD200 expression is associated with tumor progression, and blockade of the CD200/CD200R signaling pathway has been reported to enhance anti-tumor immune responses. This study presents a preliminary evaluation of the therapeutic effects of local HT combined with anti-CD200 blockade in a preclinical mouse model. EMT6 tumors were established in Balb/c mice via subcutaneous inoculation. Local HT was applied on days 7, 8, and 9 post-inoculation, and anti-CD2","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:18:14.316Z","creation":"2026-07-11T03:11:48.179Z"},"accession":"S-EPMC12945981","cross_references":{"pubmed":["41746550"],"doi":["10.1007/s12032-026-03240-7"]}}