biostudies-literatureUnknown56(3)Hata A<h4>Purpose</h4>Recent randomized controlled trials have shown the non-inferiority of sublobar-to-lobar resection for small peripheral non-small cell lung cancer (NSCLC); however, whether wedge resection (WR) or anatomical segmentectomy (SG) is superior remains unclear. We hypothesized that ground-glass opacity (GGO) is associated with the outcomes of WR and SG.<h4>Methods</h4>Between 2010 and 2022, 219 consecutive patients with clinical stage IA peripheral NSCLC who underwent sublobar resection for frailty at our institution were retrospectively reviewed. Based on the high-resolution computed tomography findings, the tumors were classified into two groups: part-solid (GGO (+)) and solid (GGO (-)). The long-term outcomes were compared between the WR and SG groups.<h4>Results</h4>In the parSurgery today301-310https://www.ebi.ac.uk/biostudies/studies/S-EPMC12946241biostudies-literatureWedge resection versus segmentectomy in peripheral clinical stage IA lung cancer concerning ground-glass opacity.PMC12946241Iwata TIto TYamamoto TOtani YSakairi YSato YHata AfalseWedge resection versus segmentectomy in peripheral clinical stage IA lung cancer concerning ground-glass opacity.<h4>Purpose</h4>Recent randomized controlled trials have shown the non-inferiority of sublobar-to-lobar resection for small peripheral non-small cell lung cancer (NSCLC); however, whether wedge resection (WR) or anatomical segmentectomy (SG) is superior remains unclear. We hypothesized that ground-glass opacity (GGO) is associated with the outcomes of WR and SG.<h4>Methods</h4>Between 2010 and 2022, 219 consecutive patients with clinical stage IA peripheral NSCLC who underwent sublobar resection for frailty at our institution were retrospectively reviewed. Based on the high-resolution computed tomography findings, the tumors were classified into two groups: part-solid (GGO (+)) and solid (GGO (-)). The long-term outcomes were compared between the WR and SG groups.<h4>Results</h4>In the par2026-01-01T00:00:00Z2026 Mar2026-07-16T22:15:12.162Z2026-07-12T03:08:48.688ZS-EPMC129462414098205610.1007/s00595-025-03137-4