{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zaitsev AV"],"funding":["American Heart Association","Virginia Polytechnic Institute and State University","College of Agriculture and Life Sciences, Virginia Polytechnic Institute and State University","NIH HHS"],"pagination":["7705"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12946242"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Several groups have demonstrated that PERM1 is a positive regulator of mitochondrial bioenergetics in the heart. However, conflicting results have emerged regarding whether PERM1 loss of function affects cardiac contractility. Here, we present data from a retrospective study compiling echocardiography data from all Perm1-knockout (Perm1-KO) mice and their wild-type (WT) littermates used for various molecular biology experiments in our laboratory between April 2022 and September 2023. This yielded an atypically large number of subjects per group-84 WT mice and 88 Perm1-KO mice. We analyzed echocardiography-derived parameters of left ventricular (LV) systolic function. The ejection fraction (EF) was 65.43 ± 7.13% in WT vs. 53.98 ± 8.80% in Perm1-KO mice (p = 5.21E-17, unpaired t-test). Other"],"journal":["Scientific reports"],"pubmed_title":["Analysis of systolic cardiac function in PERM1-knockout mice using large cohorts of animals."],"pmcid":["PMC12946242"],"funding_grant_id":["R01HL156667","Virginia Tech Research and Innovation Postdoctoral Scholarship","FBRI Virginia Tech Carilion Operation Fund","24POST1186520"],"pubmed_authors":["Warren JS","Zaitsev AV","Goode B","Sreedevi K"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of systolic cardiac function in PERM1-knockout mice using large cohorts of animals.","description":"Several groups have demonstrated that PERM1 is a positive regulator of mitochondrial bioenergetics in the heart. However, conflicting results have emerged regarding whether PERM1 loss of function affects cardiac contractility. Here, we present data from a retrospective study compiling echocardiography data from all Perm1-knockout (Perm1-KO) mice and their wild-type (WT) littermates used for various molecular biology experiments in our laboratory between April 2022 and September 2023. This yielded an atypically large number of subjects per group-84 WT mice and 88 Perm1-KO mice. We analyzed echocardiography-derived parameters of left ventricular (LV) systolic function. The ejection fraction (EF) was 65.43 ± 7.13% in WT vs. 53.98 ± 8.80% in Perm1-KO mice (p = 5.21E-17, unpaired t-test). Other","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:21:57.011Z","creation":"2026-07-13T03:07:25.264Z"},"accession":"S-EPMC12946242","cross_references":{"pubmed":["41654599"],"doi":["10.1038/s41598-026-37420-2"]}}